Role of the adjacent stroma cells in prostate cancer development and progression: Synergy between TGF-β and IGF signaling

Chung Lee; Zhenyu Jia; Farah Rahmatpanah; Qiang Zhang; Xiaolin Zi; Michael McClelland; Dan Mercola

doi:10.1155/2014/502093

Role of the adjacent stroma cells in prostate cancer development and progression: Synergy between TGF-β and IGF signaling

Chung Lee^*, Zhenyu Jia, Farah Rahmatpanah, Qiang Zhang, Xiaolin Zi, Michael McClelland, Dan Mercola

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.

Original language	English (US)
Article number	502093
Journal	BioMed Research International
Volume	2014
DOIs	https://doi.org/10.1155/2014/502093
State	Published - 2014

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Role of the adjacent stroma cells in prostate cancer development and progression: Synergy between TGF-β and IGF signaling",

abstract = "This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.",

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T1 - Role of the adjacent stroma cells in prostate cancer development and progression

T2 - Synergy between TGF-β and IGF signaling

AU - Lee, Chung

AU - Jia, Zhenyu

AU - Rahmatpanah, Farah

AU - Zhang, Qiang

AU - Zi, Xiaolin

AU - McClelland, Michael

AU - Mercola, Dan

PY - 2014

Y1 - 2014

N2 - This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.

AB - This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.

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Role of the adjacent stroma cells in prostate cancer development and progression: Synergy between TGF-β and IGF signaling

Abstract

ASJC Scopus subject areas

UN SDGs

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