Role of the adjacent stroma cells in prostate cancer development and progression

Synergy between TGF-β and IGF signaling

Chung Lee*, Zhenyu Jia, Farah Rahmatpanah, Qiang Zhang, Xiaolin Zi, Michael McClelland, Dan Mercola

*Corresponding author for this work

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.

Original languageEnglish (US)
Article number502093
JournalBioMed Research International
Volume2014
DOIs
StatePublished - Jan 1 2014

Fingerprint

Transforming Growth Factor beta
Prostatic Neoplasms
Stromal Cells
Insulin-Like Growth Factor I
Prostate
Insulin-Like Growth Factor II
Tumor Microenvironment
Somatomedins
Tumors
Neoplasms
Carcinogenesis
Epithelial Cells
Maintenance
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

@article{aa0daf721b2e42fd8f7fd5d1dda64b51,
title = "Role of the adjacent stroma cells in prostate cancer development and progression: Synergy between TGF-β and IGF signaling",
abstract = "This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.",
author = "Chung Lee and Zhenyu Jia and Farah Rahmatpanah and Qiang Zhang and Xiaolin Zi and Michael McClelland and Dan Mercola",
year = "2014",
month = "1",
day = "1",
doi = "10.1155/2014/502093",
language = "English (US)",
volume = "2014",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

Role of the adjacent stroma cells in prostate cancer development and progression : Synergy between TGF-β and IGF signaling. / Lee, Chung; Jia, Zhenyu; Rahmatpanah, Farah; Zhang, Qiang; Zi, Xiaolin; McClelland, Michael; Mercola, Dan.

In: BioMed Research International, Vol. 2014, 502093, 01.01.2014.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Role of the adjacent stroma cells in prostate cancer development and progression

T2 - Synergy between TGF-β and IGF signaling

AU - Lee, Chung

AU - Jia, Zhenyu

AU - Rahmatpanah, Farah

AU - Zhang, Qiang

AU - Zi, Xiaolin

AU - McClelland, Michael

AU - Mercola, Dan

PY - 2014/1/1

Y1 - 2014/1/1

N2 - This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.

AB - This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.

UR - http://www.scopus.com/inward/record.url?scp=84904187772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904187772&partnerID=8YFLogxK

U2 - 10.1155/2014/502093

DO - 10.1155/2014/502093

M3 - Review article

VL - 2014

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 502093

ER -