Role of the adrenal in an experimental myopathy

Ralph W. Kuncl; Herbert Y. Meltzer

doi:10.1016/0014-4886(77)90068-1

Role of the adrenal in an experimental myopathy

Ralph W. Kuncl, Herbert Y. Meltzer^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We studied the effect of adrenalectomy on an experimental myopathy which is characterized by subtle morphologic alteration and profound enzyme efflux in rats. Adrenalectomy greatly reduced (by > 85%) the increase in plasma creatine phosphokinase activity and myofibrillar disruption which follow treatment with phencyclidine and restraint. Adrenal demedullation had an identical effect. A single replacement dose of epinephrine in the adrenal-demedullated rat restored the myopathic response. Denervation and β-adrenergic receptor blockade similarly prevented the development of the myopathy. These findings suggest that intense muscle activity, with increased demand for oxygen, can produce extensive architectural changes and elevate plasma creatine phosphokinase activity when adrenal epinephrine is present, perhaps via the calorigenic effect, increasing the rate of oxygen utilization, or via well known effects of epinephrine on neuromuscular transmission or contraction.

Original language	English (US)
Pages (from-to)	322-330
Number of pages	9
Journal	Experimental Neurology
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/0014-4886(77)90068-1
State	Published - Nov 1977

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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title = "Role of the adrenal in an experimental myopathy",

abstract = "We studied the effect of adrenalectomy on an experimental myopathy which is characterized by subtle morphologic alteration and profound enzyme efflux in rats. Adrenalectomy greatly reduced (by > 85%) the increase in plasma creatine phosphokinase activity and myofibrillar disruption which follow treatment with phencyclidine and restraint. Adrenal demedullation had an identical effect. A single replacement dose of epinephrine in the adrenal-demedullated rat restored the myopathic response. Denervation and β-adrenergic receptor blockade similarly prevented the development of the myopathy. These findings suggest that intense muscle activity, with increased demand for oxygen, can produce extensive architectural changes and elevate plasma creatine phosphokinase activity when adrenal epinephrine is present, perhaps via the calorigenic effect, increasing the rate of oxygen utilization, or via well known effects of epinephrine on neuromuscular transmission or contraction.",

author = "Kuncl, {Ralph W.} and Meltzer, {Herbert Y.}",

note = "Funding Information: 1 Supported by U.S. Public Health Service Grants 18,396 and 16,127. Dr. Meltzer is the recipient of RCSA MH 47,808. Dr. Kuncl is the recipient of USPHS STOSGM01939-09 (MSTP) . Address reprint requests to the authors at the Department of Psychiatry. The authors wish to acknowledge their appreciation to Sally Schles-singer, Rita Kaluskar, Judy Siegel, and Jane Rosen for technical assistance and to Kathy Hicks for assistance in preparation of the manuscript.",

year = "1977",

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doi = "10.1016/0014-4886(77)90068-1",

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N2 - We studied the effect of adrenalectomy on an experimental myopathy which is characterized by subtle morphologic alteration and profound enzyme efflux in rats. Adrenalectomy greatly reduced (by > 85%) the increase in plasma creatine phosphokinase activity and myofibrillar disruption which follow treatment with phencyclidine and restraint. Adrenal demedullation had an identical effect. A single replacement dose of epinephrine in the adrenal-demedullated rat restored the myopathic response. Denervation and β-adrenergic receptor blockade similarly prevented the development of the myopathy. These findings suggest that intense muscle activity, with increased demand for oxygen, can produce extensive architectural changes and elevate plasma creatine phosphokinase activity when adrenal epinephrine is present, perhaps via the calorigenic effect, increasing the rate of oxygen utilization, or via well known effects of epinephrine on neuromuscular transmission or contraction.

AB - We studied the effect of adrenalectomy on an experimental myopathy which is characterized by subtle morphologic alteration and profound enzyme efflux in rats. Adrenalectomy greatly reduced (by > 85%) the increase in plasma creatine phosphokinase activity and myofibrillar disruption which follow treatment with phencyclidine and restraint. Adrenal demedullation had an identical effect. A single replacement dose of epinephrine in the adrenal-demedullated rat restored the myopathic response. Denervation and β-adrenergic receptor blockade similarly prevented the development of the myopathy. These findings suggest that intense muscle activity, with increased demand for oxygen, can produce extensive architectural changes and elevate plasma creatine phosphokinase activity when adrenal epinephrine is present, perhaps via the calorigenic effect, increasing the rate of oxygen utilization, or via well known effects of epinephrine on neuromuscular transmission or contraction.

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