Role of the CNS microvascular pericyte in the blood-brain barrier

Roumen Balabanov, Paula Dore-Duffy*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

253 Scopus citations

Abstract

Pericytes are a very important cellular constituent of the blood-brain barrier. They play a regulatory role in brain angiogenesis, endothelial cell tight junction formation, blood-brain barrier differentiation, as well as contribute to the microvascular vasodynamic capacity and structural stability. Central nervous system pericytes express macrophage functions and are actively involved in the neuroimmune network operating at the blood- brain barrier. They exhibit unique functional characteristics critical for the pathogenesis of a number of cerebrovascular, neurodegenerative, and neuroimmune diseases.

Original languageEnglish (US)
Pages (from-to)637-644
Number of pages8
JournalJournal of Neuroscience Research
Volume53
Issue number6
DOIs
StatePublished - Sep 15 1998

Keywords

  • Angiogenesis
  • Blood-brain barrier
  • Central nervous system
  • Endothelial cells
  • Macrophage
  • Microvasculature
  • Pericyte

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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