Role of the epithelial cell-specific clathrin adaptor complex AP-1B in cell polarity

Heike Fölsch*

*Corresponding author for this work

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Epithelial cells are important for organ development and function. To this end, they polarize their plasma membrane into biochemically and physically distinct membrane domains. The apical membrane faces the luminal site of an organ and the basolateral domain is in contact with the basement membrane and neighboring cells. To establish and maintain this polarity it is important that newly synthesized and endocytic cargos are correctly sorted according to their final destinations at either membrane. Sorting takes place at one of 2 major sorting stations in the cells, the trans-Golgi network (TGN) and recycling endosomes (REs). Polarized sorting may involve epithelial cell-specific sorting adaptors like the AP-1B clathrin adaptor complex. AP-1B facilitates basolateral sorting from REs. This review will discuss various aspects of basolateral sorting in epithelial cells with a special emphasis on AP-1B.

Original languageEnglish (US)
JournalCellular Logistics
Volume5
Issue number2
DOIs
StatePublished - Jan 1 2015

Keywords

  • AP-1B
  • Basolateral membrane
  • Cell polarity
  • Epithelial cells
  • Recylcing endosomes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Cell Biology

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