Role of the fibrinolytic system in preventing myocardial infarction

D. E. Vaughan*, J. L. Rouleau, M. A. Pfeffer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Activation of the renin-angiotensin system (RAS) has been implicated in the pathogenesis of acute myocardial infarction (AMI). Similarly, reduced fibrinolytic activity has been associated with an increased risk of AMI. Evidence is now accumulating that the RAS plays an important role in the regulation of fibrinolysis and that pharmacological interruption of the RAS exerts a positive effect on endogenous fibrinolytic balance. This relationship appears to provide a partial explanation for the newly recognized effect of angiotensin converting enzyme inhibitors in preventing AMI.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalEuropean heart journal
Issue numberSUPPL. K
StatePublished - 1995


  • Angiotensin converting enzyme
  • Fibrinolysis
  • Plasminogen activator inhibitor-1
  • Renin-angiotensin system
  • Tissue-type plasminogen activator

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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