Role of the mitochondrial ATP-sensitive K+ channels in cardioprotection

Hossein Ardehali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The mitochondrial ATP-sensitive K+ (mitoKATP) channel was discovered more than a decade ago. Since then, several pharmacological studies have identified agents that target this channel some of which selectively target mitoKATP. These and other studies have also suggested that mitoKATP plays a key role in the process of ischemic preconditioning (IPC) and prevention of apoptosis. The mechanism by which mitoKATP exerts its protective effects is unclear, however, changes in mitochondrial Ca2+ uptake and levels of reactive oxygen species, and mitochondrial matrix swelling are believed to be involved. Despite major advances, several important issues regarding mitoKATP remain unanswered. These questions include, but are not limited to: the molecular structure of mitoKATP, the downstream and upstream mechanisms that leads to IPC and cell death, and the pharmacological profile of the channel. This review attempts to provide an up-to-date overview of the role of mitoK ATP in cardioprotection.

Original languageEnglish (US)
Pages (from-to)379-390
Number of pages12
JournalActa biochimica Polonica
Volume51
Issue number2
DOIs
StatePublished - 2004

Keywords

  • Apoptosis
  • Diazoxide
  • Ischemic preconditioning
  • Mitochondria
  • Potassium channel

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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