Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro

Robert T. Chatterton, John P. Lydon, Rajendra G. Mehta, Esnar T. Mateo, Ashley Pletz, V. Craig Jordan

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Glands of wild-type (WT) and progesterone receptor knockout (PRKO) mice were exposed to 7,12-dimethylbenz[a]anthracene (DMBA) while cultured in serum-free medium containing insulin, prolactin, aldosterone, and cortisol. Glands of WT but not PRKO mice responded to DMBA with epithelial hyperplasia after 10 days in this medium. After culture without prolactin and adrenocortical hormones for an additional 14 days, hyperplastic lesions were present only in glands of WT mice. We conclude that in the absence of PR, epithelial structures are resistant to the carcinogenic action of DMBA.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalCancer Letters
Volume188
Issue number1-2
DOIs
StatePublished - Dec 15 2002

Keywords

  • Carcinogen
  • Gene knockout
  • Mammary
  • Progesterone receptor
  • Tumor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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