Energy homeostasis depends on the expression of metabolic gene network that control the activity and anabolic and catabolic pathways. A number of nuclear receptors regulate transcription from these gene networks in metabolic tissues. Their transcriptional activity varies according to the recruitment of coactivators or corepressors. The function of the corepressor RIP140 in suppressing the expression of catabolic gene networks in adipose and muscle is the focus of this review.
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