Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature

En Ling Wu; Omar Al-Heeti; Brian M. Hoff; Janna L. Williams; Karen M. Krueger; Phillip P. Santoiemma; Nathaniel J. Rhodes

doi:10.1093/ofid/ofac392

Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature

En Ling Wu, Omar Al-Heeti, Brian M. Hoff, Janna L. Williams, Karen M. Krueger, Phillip P. Santoiemma, Nathaniel J. Rhodes^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have Mycobacterium abscessus growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42.

Original language	English (US)
Article number	ofac392
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofac392
State	Published - Aug 1 2022

Funding

Potential conflicts of interest. N. J. R. reports research support from the American Academy of Colleges of Pharmacy and Paratek Pharmaceuticals, consulting fees from Third Pole Therapeutics, and holds patent number US-10688195-B2, outside the present work. B. M. H. reports compensation from the American College of Clinical Pharmacy and Midwestern University, outside the present work. J. L. W. reports consulting fees from Abbvie, outside the present work. All other authors report no potential conflicts of interest.

Keywords

NTM
mycobacterial infections
pharmacokinetics
therapeutic drug monitoring
ventriculitis
ventriculoperitoneal shunt

ASJC Scopus subject areas

Oncology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofac392

Cite this

Wu, E. L., Al-Heeti, O., Hoff, B. M., Williams, J. L., Krueger, K. M., Santoiemma, P. P., & Rhodes, N. J. (2022). Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature. Open Forum Infectious Diseases, 9(8), Article ofac392. https://doi.org/10.1093/ofid/ofac392

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abstract = "A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have Mycobacterium abscessus growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42.",

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Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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