@article{17e27a4531f74ded91e7e44f3efea473,
title = "Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature",
abstract = "A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have Mycobacterium abscessus growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42.",
keywords = "NTM, mycobacterial infections, pharmacokinetics, therapeutic drug monitoring, ventriculitis, ventriculoperitoneal shunt",
author = "Wu, {En Ling} and Omar Al-Heeti and Hoff, {Brian M.} and Williams, {Janna L.} and Krueger, {Karen M.} and Santoiemma, {Phillip P.} and Rhodes, {Nathaniel J.}",
note = "Funding Information: Potential conflicts of interest. N. J. R. reports research support from the American Academy of Colleges of Pharmacy and Paratek Pharmaceuticals, consulting fees from Third Pole Therapeutics, and holds patent number US-10688195-B2, outside the present work. B. M. H. reports compensation from the American College of Clinical Pharmacy and Midwestern University, outside the present work. J. L. W. reports consulting fees from Abbvie, outside the present work. All other authors report no potential conflicts of interest. Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2022",
month = aug,
day = "1",
doi = "10.1093/ofid/ofac392",
language = "English (US)",
volume = "9",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "8",
}
