Role of thymic reconstitution in the outcome of AIDS-related PML

Spyridon G. Chalkias, Sarah Gheuens, Evelyn Bord, Stephanie Batson, Igor J. Koralnik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Implications of thymopoiesis in AIDS-related opportunistic infections remain unexplored. We used progressive multifocal leukoencephalopathy (PML), caused by JC virus (JCV), as an opportunistic infection model, and we simultaneously investigated thymic output and T-cell responses against JCV in 22 patients with PML treated with combined antiretroviral therapy. Thymic output was significantly associated with JCV-specific CD4+ and CD8+ T-cell responses and improved survival. Our data suggest that patients with AIDS-related PML and impaired thymopoiesis are less likely to develop a robust JCV-specific cellular immune response and consequently are at an increased risk for a poor clinical outcome.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume70
Issue number4
DOIs
StatePublished - Dec 1 2015

Keywords

  • HIV
  • JC virus
  • Progressive multifocal leukoencephalopathy
  • Thymus

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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