Role of thymic reconstitution in the outcome of AIDS-related PML

Spyridon G. Chalkias; Sarah Gheuens; Evelyn Bord; Stephanie Batson; Igor J. Koralnik

doi:10.1097/qai.0000000000000754

Role of thymic reconstitution in the outcome of AIDS-related PML

Spyridon G. Chalkias, Sarah Gheuens, Evelyn Bord, Stephanie Batson, Igor J. Koralnik^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Implications of thymopoiesis in AIDS-related opportunistic infections remain unexplored. We used progressive multifocal leukoencephalopathy (PML), caused by JC virus (JCV), as an opportunistic infection model, and we simultaneously investigated thymic output and T-cell responses against JCV in 22 patients with PML treated with combined antiretroviral therapy. Thymic output was significantly associated with JCV-specific CD4⁺ and CD8⁺ T-cell responses and improved survival. Our data suggest that patients with AIDS-related PML and impaired thymopoiesis are less likely to develop a robust JCV-specific cellular immune response and consequently are at an increased risk for a poor clinical outcome.

Original language	English (US)
Pages (from-to)	357-361
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	70
Issue number	4
DOIs	https://doi.org/10.1097/qai.0000000000000754
State	Published - Dec 1 2015

Keywords

HIV
JC virus
Progressive multifocal leukoencephalopathy
Thymus

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/qai.0000000000000754

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title = "Role of thymic reconstitution in the outcome of AIDS-related PML",

abstract = "Implications of thymopoiesis in AIDS-related opportunistic infections remain unexplored. We used progressive multifocal leukoencephalopathy (PML), caused by JC virus (JCV), as an opportunistic infection model, and we simultaneously investigated thymic output and T-cell responses against JCV in 22 patients with PML treated with combined antiretroviral therapy. Thymic output was significantly associated with JCV-specific CD4+ and CD8+ T-cell responses and improved survival. Our data suggest that patients with AIDS-related PML and impaired thymopoiesis are less likely to develop a robust JCV-specific cellular immune response and consequently are at an increased risk for a poor clinical outcome.",

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AU - Chalkias, Spyridon G.

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AU - Bord, Evelyn

AU - Batson, Stephanie

AU - Koralnik, Igor J.

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AB - Implications of thymopoiesis in AIDS-related opportunistic infections remain unexplored. We used progressive multifocal leukoencephalopathy (PML), caused by JC virus (JCV), as an opportunistic infection model, and we simultaneously investigated thymic output and T-cell responses against JCV in 22 patients with PML treated with combined antiretroviral therapy. Thymic output was significantly associated with JCV-specific CD4+ and CD8+ T-cell responses and improved survival. Our data suggest that patients with AIDS-related PML and impaired thymopoiesis are less likely to develop a robust JCV-specific cellular immune response and consequently are at an increased risk for a poor clinical outcome.

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Role of thymic reconstitution in the outcome of AIDS-related PML

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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