Roles and mechanisms of ankyrin-G in neuropsychiatric disorders

Sehyoun Yoon, Nicolas H. Piguel, Peter Penzes*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Ankyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder (BD), schizophrenia (SZ), and autism spectrum disorder (ASD). Within neurons, ankyrin-G plays an important role in localizing proteins to the axon initial segment and nodes of Ranvier or to the dendritic shaft and spines. In this review, we describe the expression patterns of ankyrin-G isoforms, which vary according to the stage of brain development, and consider their functional differences. Furthermore, we discuss how posttranslational modifications of ankyrin-G affect its protein expression, interactions, and subcellular localization. Understanding these mechanisms leads us to elucidate potential pathways of pathogenesis in neurodevelopmental and psychiatric disorders, including BD, SZ, and ASD, which are caused by rare pathogenic mutations or changes in the expression levels of ankyrin-G in the brain.

Original languageEnglish (US)
Pages (from-to)867-877
Number of pages11
JournalExperimental and Molecular Medicine
Issue number7
StatePublished - Jul 2022

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Clinical Biochemistry


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