Roles for transforming growth factor beta superfamily proteins in early folliculogenesis

Daniel J. Trombly, Teresa K. Woodruff, Kelly E. Mayo

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


Primordial follicle formation and the subsequent transition of follicles to the primary and secondary stages encompass the early events during folliculogenesis in mammals. These processes establish the ovarian follicle pool and prime follicles for entry into subsequent growth phases during the reproductive cycle. Perturbations during follicle formation can affect the size of the primordial follicle pool significantly, and alterations in follicle transition can cause follicles to arrest at immature stages or result in premature depletion of the follicle reserve. Determining the molecular events that regulate primordial follicle formation and early follicle growth may lead to the development of new fertility treatments. Over the last decade, many of the growth factors and signaling proteins that mediate the early stages of folliculogenesis have been identified using mouse genetic models, in vivo injection studies, and ex vivo organ culture approaches. These studies reveal important roles for the transforming growth factor β (TGF-β) superfamily of proteins in the ovary. This article reviews these roles for TGF-β family proteins and focuses in particular on work from our laboratories on the functions of activin in early folliculogenesis.

Original languageEnglish (US)
Pages (from-to)14-23
Number of pages10
JournalSeminars in reproductive medicine
Issue number1
StatePublished - Jan 2009


  • Activin
  • Folliculogenesis
  • Growth factors
  • Primordial follicle
  • Tgf-β superfamily

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

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