Abstract
Transient receptor potential (TRP) channels are a ubiquitously expressed multi-family group of cation channels that are critical to signaling events in many tissues. Their roles have been documented in many physiologic and pathologic conditions. Nevertheless, direct studies of their roles in maintain barrier function in endothelial and epithelia are relatively infrequent. This seems somewhat surprising considering that calcium ion concentrations are known to regulate barrier function. This short review provides an introduction to TRP channels and reviews some of the work in which investigators directly studied the role of TRP channels in endothelial permeability to electric current, solute, or leukocytes during the inflammatory response.
Original language | English (US) |
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Article number | e1331722 |
Journal | Tissue Barriers |
Volume | 5 |
Issue number | 2 |
DOIs | |
State | Published - Apr 3 2017 |
Keywords
- TRP channels
- calcium signaling
- endothelium
- epithelium
- junctions
- permeability
ASJC Scopus subject areas
- Biochemistry
- Histology
- Cell Biology