Roles of transient receptor potential channels in regulation of vascular and epithelial barriers

Evan W. Weber, William A. Muller*

*Corresponding author for this work

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Transient receptor potential (TRP) channels are a ubiquitously expressed multi-family group of cation channels that are critical to signaling events in many tissues. Their roles have been documented in many physiologic and pathologic conditions. Nevertheless, direct studies of their roles in maintain barrier function in endothelial and epithelia are relatively infrequent. This seems somewhat surprising considering that calcium ion concentrations are known to regulate barrier function. This short review provides an introduction to TRP channels and reviews some of the work in which investigators directly studied the role of TRP channels in endothelial permeability to electric current, solute, or leukocytes during the inflammatory response.

Original languageEnglish (US)
Article numbere1331722
JournalTissue Barriers
Volume5
Issue number2
DOIs
StatePublished - Apr 3 2017

Keywords

  • TRP channels
  • calcium signaling
  • endothelium
  • epithelium
  • junctions
  • permeability

ASJC Scopus subject areas

  • Biochemistry
  • Histology
  • Cell Biology

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