ROS-dependent signal transduction

Colleen R. Reczek, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalReview article

372 Scopus citations

Abstract

Reactive oxygen species (ROS) are no longer viewed as just a toxic by-product of mitochondrial respiration, but are now appreciated for their role in regulating a myriad of cellular signaling pathways. H2O2, a type of ROS, is a signaling molecule that confers target specificity through thiol oxidation. Although redox-dependent signaling has been implicated in numerous cellular processes, the mechanism by which the ROS signal is transmitted to its target protein in the face of highly reactive and abundant antioxidants is not fully understood. In this review of redox-signaling biology, we discuss the possible mechanisms for H2O2-dependent signal transduction.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume33
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Cell Biology

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