ROS links glucose metabolism to breast cancer stem cell and emt phenotype

Michael S. Schieber, Navdeep Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort survey

71 Citations (Scopus)

Abstract

Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decreased reactive oxygen species levels.

Original languageEnglish (US)
Pages (from-to)265-267
Number of pages3
JournalCancer Cell
Volume23
Issue number3
DOIs
StatePublished - Mar 18 2013

Fingerprint

Neoplastic Stem Cells
Breast Neoplasms
Phenotype
Glucose
Epithelial-Mesenchymal Transition
Reactive Oxygen Species
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

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title = "ROS links glucose metabolism to breast cancer stem cell and emt phenotype",
abstract = "Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decreased reactive oxygen species levels.",
author = "Schieber, {Michael S.} and Navdeep Chandel",
year = "2013",
month = "3",
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doi = "10.1016/j.ccr.2013.02.021",
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volume = "23",
pages = "265--267",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",

}

ROS links glucose metabolism to breast cancer stem cell and emt phenotype. / Schieber, Michael S.; Chandel, Navdeep.

In: Cancer Cell, Vol. 23, No. 3, 18.03.2013, p. 265-267.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - ROS links glucose metabolism to breast cancer stem cell and emt phenotype

AU - Schieber, Michael S.

AU - Chandel, Navdeep

PY - 2013/3/18

Y1 - 2013/3/18

N2 - Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decreased reactive oxygen species levels.

AB - Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decreased reactive oxygen species levels.

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U2 - 10.1016/j.ccr.2013.02.021

DO - 10.1016/j.ccr.2013.02.021

M3 - Short survey

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JO - Cancer Cell

JF - Cancer Cell

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