ROS Promotes Cancer Cell Survival through Calcium Signaling

Colleen R. Reczek, Navdeep Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort survey

6 Citations (Scopus)

Abstract

To avoid reactive oxygen species (ROS)-induced cell death, cancer cells increase their antioxidant defense system. In this issue of Cancer Cell, Takahashi et al. identify a novel, non-canonical oxidative stress defense mechanism involving TRPA1, a redox-sensitive Ca2+ channel, and the upregulation of anti-apoptotic pathways to promote cancer cell survival. To avoid reactive oxygen species (ROS)-induced cell death, cancer cells increase their antioxidant defense system. In this issue of Cancer Cell, Takahashi et al. identify a novel, non-canonical oxidative stress defense mechanism involving TRPA1, a redox-sensitive Ca2+ channel, and the upregulation of anti-apoptotic pathways to promote cancer cell survival.

Original languageEnglish (US)
Pages (from-to)949-951
Number of pages3
JournalCancer Cell
Volume33
Issue number6
DOIs
StatePublished - Jun 11 2018

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Calcium Signaling
Reactive Oxygen Species
Cell Survival
Neoplasms
Oxidation-Reduction
Oxidative Stress
Cell Death
Up-Regulation
Antioxidants

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Reczek, Colleen R. ; Chandel, Navdeep. / ROS Promotes Cancer Cell Survival through Calcium Signaling. In: Cancer Cell. 2018 ; Vol. 33, No. 6. pp. 949-951.
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ROS Promotes Cancer Cell Survival through Calcium Signaling. / Reczek, Colleen R.; Chandel, Navdeep.

In: Cancer Cell, Vol. 33, No. 6, 11.06.2018, p. 949-951.

Research output: Contribution to journalShort survey

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