ROS Promotes Cancer Cell Survival through Calcium Signaling

Colleen R. Reczek, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort survey

18 Scopus citations

Abstract

To avoid reactive oxygen species (ROS)-induced cell death, cancer cells increase their antioxidant defense system. In this issue of Cancer Cell, Takahashi et al. identify a novel, non-canonical oxidative stress defense mechanism involving TRPA1, a redox-sensitive Ca 2+ channel, and the upregulation of anti-apoptotic pathways to promote cancer cell survival. To avoid reactive oxygen species (ROS)-induced cell death, cancer cells increase their antioxidant defense system. In this issue of Cancer Cell, Takahashi et al. identify a novel, non-canonical oxidative stress defense mechanism involving TRPA1, a redox-sensitive Ca 2+ channel, and the upregulation of anti-apoptotic pathways to promote cancer cell survival.

Original languageEnglish (US)
Pages (from-to)949-951
Number of pages3
JournalCancer Cell
Volume33
Issue number6
DOIs
StatePublished - Jun 11 2018

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Fingerprint Dive into the research topics of 'ROS Promotes Cancer Cell Survival through Calcium Signaling'. Together they form a unique fingerprint.

  • Cite this