ROS1 rearranged non-small cell lung cancer brain metastases respond to low dose radiotherapy

Rimas V. Lukas*, Yasmin Hasan, Martin K. Nicholas, Ravi Salgia

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We present a young woman with ROS1 gene rearranged non-small cell lung cancer (NSCLC) with brain metastases. ROS is a proto-oncogene tyrosine protein kinase. The patient received a partial course of whole brain radiation therapy and experienced a sustained partial response in the brain. We hypothesize that ROS1 rearranged NSCLC brain metastases may be particularly sensitive to radiation therapy.

Original languageEnglish
Pages (from-to)1978-1979
Number of pages2
JournalJournal of Clinical Neuroscience
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2015

Keywords

  • Brain metastases
  • Crizotinib
  • Non-small cell lung cancer
  • Radiotherapy
  • ROS1

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

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