Abstract
We present a young woman with ROS1 gene rearranged non-small cell lung cancer (NSCLC) with brain metastases. ROS is a proto-oncogene tyrosine protein kinase. The patient received a partial course of whole brain radiation therapy and experienced a sustained partial response in the brain. We hypothesize that ROS1 rearranged NSCLC brain metastases may be particularly sensitive to radiation therapy.
Original language | English |
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Pages (from-to) | 1978-1979 |
Number of pages | 2 |
Journal | Journal of Clinical Neuroscience |
Volume | 22 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2015 |
Keywords
- Brain metastases
- Crizotinib
- Non-small cell lung cancer
- Radiotherapy
- ROS1
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Physiology (medical)
- General Medicine