Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

Yu Cheng, Megan E. Muroski, Dorothée C.M.C. Petit, Rhodri Mansell, Tarun Vemulkar, Ramin A. Morshed, Yu Han, Irina V Balyasnikova, Craig Michael Horbinski, Xinlei Huang, Lingjiao Zhang, Russell P. Cowburn, Maciej S Lesniak*

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field using magnetic particles has not yet been demonstrated. To-date, induced cancer cell death via the oscillation of nanoparticles under a low-frequency magnetic field has only been observed in vitro. In this report, we demonstrate the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. The internalized nanomagnets align themselves to the plane of the rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure inducing programmed cell death. In vivo, the magnetic field treatment successfully reduces brain tumor size and increases the survival rate of mice bearing intracranial glioma xenografts, without adverse side effects. This study demonstrates a novel approach of controlling magnetic particles for treating malignant glioma that should be applicable to treat a wide range of cancers.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalJournal of Controlled Release
Volume223
DOIs
StatePublished - Feb 10 2016

Fingerprint

Magnetic Fields
Glioma
Neoplasms
Cell Death
Heterografts
Brain Neoplasms
Nanoparticles
Fever
Pharmaceutical Preparations

Keywords

  • Magnetic field
  • Magnetic particles
  • Malignant glioma
  • Mechanical destruction

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Cheng, Yu ; Muroski, Megan E. ; Petit, Dorothée C.M.C. ; Mansell, Rhodri ; Vemulkar, Tarun ; Morshed, Ramin A. ; Han, Yu ; Balyasnikova, Irina V ; Horbinski, Craig Michael ; Huang, Xinlei ; Zhang, Lingjiao ; Cowburn, Russell P. ; Lesniak, Maciej S. / Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma. In: Journal of Controlled Release. 2016 ; Vol. 223. pp. 75-84.
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Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma. / Cheng, Yu; Muroski, Megan E.; Petit, Dorothée C.M.C.; Mansell, Rhodri; Vemulkar, Tarun; Morshed, Ramin A.; Han, Yu; Balyasnikova, Irina V; Horbinski, Craig Michael; Huang, Xinlei; Zhang, Lingjiao; Cowburn, Russell P.; Lesniak, Maciej S.

In: Journal of Controlled Release, Vol. 223, 10.02.2016, p. 75-84.

Research output: Contribution to journalArticle

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