Rough-and-tumble play induces resilience to stress in rats

Jeffrey Burgdorf*, Roger A. Kroes, Joseph R. Moskal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Positive emotions have been shown to induce resilience to stress in humans, as well as increase cognitive abilities (learning, memory, and problem solving) and improve overall health. In rats, frequency modulated 50-kHz ultrasonic vocalizations (hedonic 50 kHz) reflect a positive affective state and are best elicited by rough-and-tumble play. A well-established rat chronic unpredictable stress paradigm was used to produce a robust and long-lasting decrease in positive affect, increase in negative affect, and learned helplessness in Sprague-Dawley rats. Rough-andtumble play (3 min every 3 days) reversed stress-induced effects of chronic unpredictable stress in the Porsolt forced swim test, novelty-induced hypophagia, sucrose preference, and ultrasonic vocalization assays compared with a light touch control group. These data demonstrate that positive affect induces resilience to stress effects in rats, and that rough-and-tumble play can be used to explore the biological basis of resilience that may lead to the development of new therapeutics for stress-related disorders.

Original languageEnglish (US)
Pages (from-to)1122-1126
Number of pages5
JournalNeuroreport
Volume28
Issue number17
DOIs
StatePublished - Jan 1 2017

Keywords

  • Chronic unpredictable stress
  • Rat
  • Rough-and-tumble play
  • Stress
  • Ultrasonic vocalizations

ASJC Scopus subject areas

  • Neuroscience(all)

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