rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Laura J. Rasmussen-Torvik*, Abigail S. Baldridge, Jennifer A. Pacheco, Sharon A. Aufox, Kwang Youn A. Kim, Jonathan C. Silverstein, Erwin W. Denham, Eric Hungness, Maureen E. Smith, Philip Greenland

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p =.004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p <.05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

Original languageEnglish (US)
Pages (from-to)2225-2229
Number of pages5
JournalObesity Surgery
Volume25
Issue number11
DOIs
StatePublished - Nov 1 2015

Keywords

  • Bariatric surgery
  • Long-term weight loss
  • Obesity GWAS
  • Predictors
  • Repeated measures
  • Roux-en-Y gastric bypass
  • SNP

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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