rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Laura J. Rasmussen-Torvik; Abigail S. Baldridge; Jennifer A. Pacheco; Sharon A. Aufox; Kwang Youn A. Kim; Jonathan C. Silverstein; Erwin W. Denham; Eric Hungness; Maureen E. Smith; Philip Greenland

doi:10.1007/s11695-015-1872-7

rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Laura J. Rasmussen-Torvik^*, Abigail S. Baldridge, Jennifer A. Pacheco, Sharon A. Aufox, Kwang Youn A. Kim, Jonathan C. Silverstein, Erwin W. Denham, Eric Hungness, Maureen E. Smith, Philip Greenland

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p =.004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p <.05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

Original language	English (US)
Pages (from-to)	2225-2229
Number of pages	5
Journal	Obesity Surgery
Volume	25
Issue number	11
DOIs	https://doi.org/10.1007/s11695-015-1872-7
State	Published - Nov 1 2015

Keywords

Bariatric surgery
Long-term weight loss
Obesity GWAS
Predictors
Repeated measures
Roux-en-Y gastric bypass
SNP

ASJC Scopus subject areas

Surgery
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11695-015-1872-7

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title = "rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery",

abstract = "We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p =.004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p <.05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.",

keywords = "Bariatric surgery, Long-term weight loss, Obesity GWAS, Predictors, Repeated measures, Roux-en-Y gastric bypass, SNP",

author = "Rasmussen-Torvik, {Laura J.} and Baldridge, {Abigail S.} and Pacheco, {Jennifer A.} and Aufox, {Sharon A.} and Kim, {Kwang Youn A.} and Silverstein, {Jonathan C.} and Denham, {Erwin W.} and Eric Hungness and Smith, {Maureen E.} and Philip Greenland",

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doi = "10.1007/s11695-015-1872-7",

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AU - Rasmussen-Torvik, Laura J.

AU - Baldridge, Abigail S.

AU - Pacheco, Jennifer A.

AU - Aufox, Sharon A.

AU - Kim, Kwang Youn A.

AU - Silverstein, Jonathan C.

AU - Denham, Erwin W.

AU - Hungness, Eric

AU - Smith, Maureen E.

AU - Greenland, Philip

PY - 2015/11/1

Y1 - 2015/11/1

N2 - We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p =.004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p <.05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

AB - We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p =.004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p <.05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

KW - Bariatric surgery

KW - Long-term weight loss

KW - Obesity GWAS

KW - Predictors

KW - Repeated measures

KW - Roux-en-Y gastric bypass

KW - SNP

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rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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