Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery

Andrew T. Gabrielson; Logan Galansky; Tamir Sholklapper; Isabella Florissi; Chad Crigger; Kelly Harris; Nora Haney; Hiten D. Patel; Ming Hsien Wang; Charlotte Wu; John P. Gearhart; Heather N. Di Carlo

doi:10.1016/j.urology.2023.01.056

Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery

Andrew T. Gabrielson^*, Logan Galansky, Tamir Sholklapper, Isabella Florissi, Chad Crigger, Kelly Harris, Nora Haney, Hiten D. Patel, Ming Hsien Wang, Charlotte Wu, John P. Gearhart, Heather N. Di Carlo

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.

Original language	English (US)
Pages (from-to)	190-193
Number of pages	4
Journal	Urology
Volume	176
DOIs	https://doi.org/10.1016/j.urology.2023.01.056
State	Published - Jun 2023

Funding

Financial Disclosure : The authors have no conflicts of interest to disclose. This study was internally funded by the Robert Jeffs, MD Department of Pediatric Urology at Johns Hopkins Hospital.

ASJC Scopus subject areas

Urology

Access to Document

10.1016/j.urology.2023.01.056

Cite this

Gabrielson, A. T., Galansky, L., Sholklapper, T., Florissi, I., Crigger, C., Harris, K., Haney, N., Patel, H. D., Wang, M. H., Wu, C., Gearhart, J. P., & Di Carlo, H. N. (2023). Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery. Urology, 176, 190-193. https://doi.org/10.1016/j.urology.2023.01.056

@article{efed077edeea408db58a5194d5269dc8,

title = "Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery",

abstract = "This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.",

author = "Gabrielson, {Andrew T.} and Logan Galansky and Tamir Sholklapper and Isabella Florissi and Chad Crigger and Kelly Harris and Nora Haney and Patel, {Hiten D.} and Wang, {Ming Hsien} and Charlotte Wu and Gearhart, {John P.} and {Di Carlo}, {Heather N.}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = jun,

doi = "10.1016/j.urology.2023.01.056",

language = "English (US)",

volume = "176",

pages = "190--193",

journal = "Urology",

issn = "0090-4295",

publisher = "Elsevier Inc.",

}

Gabrielson, AT, Galansky, L, Sholklapper, T, Florissi, I, Crigger, C, Harris, K, Haney, N, Patel, HD, Wang, MH, Wu, C, Gearhart, JP & Di Carlo, HN 2023, 'Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery', Urology, vol. 176, pp. 190-193. https://doi.org/10.1016/j.urology.2023.01.056

TY - JOUR

T1 - Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery

AU - Gabrielson, Andrew T.

AU - Galansky, Logan

AU - Sholklapper, Tamir

AU - Florissi, Isabella

AU - Crigger, Chad

AU - Harris, Kelly

AU - Haney, Nora

AU - Patel, Hiten D.

AU - Wang, Ming Hsien

AU - Wu, Charlotte

AU - Gearhart, John P.

AU - Di Carlo, Heather N.

PY - 2023/6

Y1 - 2023/6

N2 - This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.

AB - This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.

UR - http://www.scopus.com/inward/record.url?scp=85153620668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85153620668&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2023.01.056

DO - 10.1016/j.urology.2023.01.056

M3 - Article

C2 - 36997075

AN - SCOPUS:85153620668

SN - 0090-4295

VL - 176

SP - 190

EP - 193

JO - Urology

JF - Urology

ER -

Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this