Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis

Stan L. Block; Ram Yogev; Felix Waldmeier; Kamal Hamed

doi:10.1097/INF.0b013e3182067cee

Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis

Stan L. Block, Ram Yogev, Felix Waldmeier, Kamal Hamed

Pediatrics

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

An open-label study evaluated the safety (n = 53) and pharmacokinetics (n = 8) of single-dose therapy with 1500 mg famciclovir (prodrug of penciclovir) for recurrent herpes labialis in adolescents. Mean Cmax, mean AUC0-, and clearance for penciclovir were 9.37 μg/mL, 31.8 μg • h/mL, and 38.2 L/h, respectively, and within the range extrapolated from data in adults. Adverse events were generally mild and transient.

Original language	English (US)
Pages (from-to)	525-528
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	6
DOIs	https://doi.org/10.1097/INF.0b013e3182067cee
State	Published - Jun 2011

Keywords

adolescent
famciclovir
herpes labialis
pharmacokinetics
safety

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/INF.0b013e3182067cee

Cite this

@article{1993a13a46e54562a424c590799c73ca,

title = "Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis",

abstract = "An open-label study evaluated the safety (n = 53) and pharmacokinetics (n = 8) of single-dose therapy with 1500 mg famciclovir (prodrug of penciclovir) for recurrent herpes labialis in adolescents. Mean Cmax, mean AUC0-, and clearance for penciclovir were 9.37 μg/mL, 31.8 μg • h/mL, and 38.2 L/h, respectively, and within the range extrapolated from data in adults. Adverse events were generally mild and transient.",

keywords = "adolescent, famciclovir, herpes labialis, pharmacokinetics, safety",

author = "Block, {Stan L.} and Ram Yogev and Felix Waldmeier and Kamal Hamed",

year = "2011",

month = jun,

doi = "10.1097/INF.0b013e3182067cee",

language = "English (US)",

volume = "30",

pages = "525--528",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis

AU - Block, Stan L.

AU - Yogev, Ram

AU - Waldmeier, Felix

AU - Hamed, Kamal

PY - 2011/6

Y1 - 2011/6

N2 - An open-label study evaluated the safety (n = 53) and pharmacokinetics (n = 8) of single-dose therapy with 1500 mg famciclovir (prodrug of penciclovir) for recurrent herpes labialis in adolescents. Mean Cmax, mean AUC0-, and clearance for penciclovir were 9.37 μg/mL, 31.8 μg • h/mL, and 38.2 L/h, respectively, and within the range extrapolated from data in adults. Adverse events were generally mild and transient.

AB - An open-label study evaluated the safety (n = 53) and pharmacokinetics (n = 8) of single-dose therapy with 1500 mg famciclovir (prodrug of penciclovir) for recurrent herpes labialis in adolescents. Mean Cmax, mean AUC0-, and clearance for penciclovir were 9.37 μg/mL, 31.8 μg • h/mL, and 38.2 L/h, respectively, and within the range extrapolated from data in adults. Adverse events were generally mild and transient.

KW - adolescent

KW - famciclovir

KW - herpes labialis

KW - pharmacokinetics

KW - safety

UR - http://www.scopus.com/inward/record.url?scp=79957986341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957986341&partnerID=8YFLogxK

U2 - 10.1097/INF.0b013e3182067cee

DO - 10.1097/INF.0b013e3182067cee

M3 - Article

C2 - 21178655

AN - SCOPUS:79957986341

SN - 0891-3668

VL - 30

SP - 525

EP - 528

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 6

ER -

Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this