Safety, efficacy, and PK/PD of vorasidenib in previously treated patients with mIDH1/2 hematologic malignancies: A phase 1 study

Courtney D. DiNardo*, Stéphane De Botton, Daniel A. Pollyea, Richard M. Stone, Jessica K. Altman, Amir T. Fathi, Tharin Limsakun, Min Liang, Sung Choe, Mohammad Hossain, Adriana E. Tron, Qian Meng, Stephanie M. Kapsalis, Shuchi S. Pandya, Eytan M. Stein

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

4 Scopus citations
Original languageEnglish (US)
Pages (from-to)E233-E236
JournalAmerican Journal of Hematology
Volume98
Issue number9
DOIs
StatePublished - Sep 2023

Funding

Medical writing assistance was provided by David Pertab, PhD, and Christine Ingleby, DPhil, CMPP, Excel Medical Affairs, Glasgow, UK, and supported by Servier Pharmaceuticals LLC. The study was supported by Agios Pharmaceuticals, Inc. Servier Pharmaceuticals LLC, which funded medical writing assistance, has completed acquisition of Agios' oncology business. C.D.D. has consulted for AbbVie and Servier; received research funding from AbbVie, Astex, BMS, Cleave, Foghorn, Forma, Immune‐Onc, Loxo, and Servier; received honoraria from Astellas, Bluebird Bio, BMS, Foghorn, Gilead, Immune‐Onc, Jazz, Novartis, Kura, Servier, and Takeda; has a membership of the board of directors or advisory roles with Genmab, GSK, Kura, and Notable Labs; and has stock options with Notable Labs. S.D.B. has received honoraria from AbbVie, Astellas Pharma, Bristol Myers Squibb, Jazz Pharmaceuticals, and Servier; has acted as a consultant or advisor to Bristol Myers Squibb, GlaxoSmithKline, Servier, and Syndax; has participated in speakers' bureau for AbbVie, Astellas Pharma, Bristol Myers Squibb, Jazz Pharmaceuticals, and Servier; has received research funding to his institution from Auron Therapeutics and Forma Therapeutics; and has received travel, accommodations, or expenses from AbbVie and Servier. D.A.P. has acted as a consultant or advisor to AbbVie, Celgene, Bristol Myers Squibb, Takeda, Foghorn, Aprea, Genentech, Syros, Novartis, Gilead, Astellas, Karyopharm, Syndax, Jazz, Bergen Bio, Arcellx, AstraZeneca, Kura, Ryvu, Magenta, Qihan, Zentalis, Medivir, HiberCell, and has received research funding from AbbVie, Bristol Myers Squibb, Teva, and Karyopharm. R.M.S. reports grants and personal fees from AbbVie, Agios, and Novartis; personal fees from Actinium, Astellas, BioLineRx, Celgene, Daiichi‐Sankyo, Elevate, GEMoaB, Janssen, Jazz, MacroGenics, Onconova, Syndax, Syntrix, Syros, Takeda, Trovagene, BerGenBio, Foghorn Therapeutics, GlaxoSmithKline, Aprea, Innate, Amgen, BMS, Boston Pharmaceuticals, Aptevo, Epizyme, Kura Oncology, and grants from AROG, outside the submitted work. J.K.A. has acted as a consultant or advisor for AbbVie, Astellas Pharma, BioSight, Bluebird Bio, Curio, Gilead, Kura Oncology, Kymera, Stemline Therapeutics, and Syros; received research funding from Servier; and received travel, accommodations, or travel‐related expenses from BioSight. A.T.F. has consulted for AbbVie, Agios, Amgen, Astellas, Bristol Myers Squibb, Celgene, EnClear, Forma, Genentech, Immunogen, Ipsen, Kite, Mablytics, Novartis, Orum, PureTech, Servier, and Takeda; and has received funding for clinical trials from AbbVie, Agios/Servier, and Celgene/Bristol Myers Squibb. E.M.S. has acted as a consultant or advisor to Novartis, Janssen, BMS/Celgene, Agios, Jazz Pharmaceuticals, Menarini, Genentech, Genesis Pharma, AbbVie, Neoleukin Therapeutics, Gilead Sciences, Syndax, OnCusp Therapeutics, Immunogen, CTI BioPharma Corp, Foghorn Therapeutics, Servier, Calithera Biosciences, Daiichi Sankyo, Aptose Biosciences, Ono Pharmaceutical, Blueprint Medicines, GEMoaB, Jnana Therapeutics, and Debiopharm Group; has stock or ownership in Auron Therapeutics; and has received research funding to his institution from Eisai, BMS/Celgene, Bayer, Agios, BioTheryX, Syros Pharmaceuticals, Servier, Foghorn Therapeutics, Syndax, Gilead Sciences, Cleave Biosciences, Prelude Therapeutics, and Loxo/Lilly. T.L., S.C., M.H., A.E.T., Q.M., S.M.K., and S.S.P. are employees of Servier. M.L., S.C., M.H., A.E.T., S.M.K., and S.S.P. were employees of Agios at the time of conducting these studies.

ASJC Scopus subject areas

  • Hematology

Cite this