Safety, pharmacokinetics, and efficacy of (+/-)-β-2′,3′- dideoxy-5-fluoro-3′-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients

C. Herzmann, K. Arastèh, R. L. Murphy, H. Schulbin, P. Kreckel, D. Drauz, R. F. Schinazi, A. Beard, L. Cartee, M. J. Otto*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Racivir [RCV; (+/-)-β-2′,3′-dideoxy-5-fluoro-3′- thiacytidine], a 50:50 racemic mixture of the two β nucleoside enantiomers, is currently in development for the treatment of human immunodeficiency virus type 1 (HIV-1) infections. RCV was administered once a day orally for 14 days at doses of 200, 400, or 600 mg in combination with stavudine and efavirenz to HIV-1-infected treatment-naive male volunteers in a phase Ib/IIa study. Six volunteers at each dose were monitored for a total of 35 days for tolerance, pharmacokinetics, and plasma HIV RNA levels. RCV in combination with stavudine and efavirenz was well tolerated at all doses tested. Pharmacokinetic parameters were dose proportional, and the maximum concentration of drug in serum at all doses exceeded the 90% effective concentration for wild-type HIV-1. Viral loads dropped as expected in all dosage groups, with mean reductions from 1.13 to 1.42 log10 by day 4 and 2.02 to 2.43 log10 by day 14. HIV RNA levels remained suppressed for more than 2 weeks in the absence of any additional therapy, with mean viral loads ranging from 2.1 to 2.6 log 10 below baseline through day 28. By day 35, HIV RNA levels began to increase but still remained >1 log10 below baseline levels.

Original languageEnglish (US)
Pages (from-to)2828-2833
Number of pages6
JournalAntimicrobial agents and chemotherapy
Volume49
Issue number7
DOIs
StatePublished - Jul 1 2005

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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