Abstract
The decline of oocyte quality with advanced maternal age has a detrimental effect on female fertility. However, there is limited knowledge of therapeutic options and their mechanisms to improve oocyte quality in reproductively older women. In this study, we demonstrated that supplementation of salidroside improves the oocyte quality of reproductively old mice. Salidroside improved the maturation, fertilization, and developmental competence of oocytes from reproductively old mice by maintaining the normal spindle/chromosome structure and mitochondrial function. Oocyte transcriptomic and micro-proteomic analysis revealed that salidroside restores oocyte quality by enhancing mitophagy in reproductively old mice. Our studies provide a new theoretical foundation for utilizing salidroside to improve oocyte quality in reproductively old females in the context of natural fertility or assisted reproduction.
| Original language | English (US) |
|---|---|
| Journal | Aging Cell |
| DOIs | |
| State | Accepted/In press - 2025 |
Funding
The authors thank Prof. Kui Liu and his team members Dr. Zexiong Lin, Dr. Haiwei Feng, Dr. Jiahuan Zheng, and Dr. Zhe Hu from the University of Hong Kong for their invaluable technical support with the animal experiments. This study was supported by the National Natural Science Foundation of China (No. 82371665), Shenzhen Medical Academy of Research and Translation (No. C2301007), and Shenzhen Science and Technology Program, China (Nos. RCYX20200714114705073 and KQTD20190929172749226). Elnur Babayev is supported by NIH/NICHD (K12 HD050121).
Keywords
- ART
- IVF
- aging
- egg
- mitochondria
- ovary
ASJC Scopus subject areas
- Aging
- Cell Biology