Salivary estradiol and testosterone in filipino men: Diurnal patterns and relationships with adiposity

Lee T. Gettler*, Thomas W. Mcdade, Alan B. Feranil, Sonny S. Agustin, Christopher W. Kuzawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objectives: We used detailed saliva sampling procedures to test for diurnal changes in men's salivary estradiol (E2) and testosterone (T) and assessed whether greater adiposity predicted higher E2 and T. Methods: We drew on a subsample of young adults enrolled in a long-running birth cohort study in Metro Cebu, Philippines. Subjects provided saliva samples at four time points during the day (waking, waking +40 min, early evening, and bedtime), which were assayed for E2 and T. Using these detailed hormonal data, we calculated E2 (n=29) and T (n=44) area-under-the-curve values, which provide insights on hormonal production over the study period. Results: While T declined immediately after waking and reached a nadir in the early evening, E2 did not show significant diurnal change (P≥0.1) but was positively correlated to T at multiple time points (P≤0.05). Subjects with higher adiposity (BMI, waist circumference, skinfolds) had elevated E2 secretion throughout the day (P≤0.01), but adiposity was not related to salivary T. Conclusions: Consistent with past research, our results indicate that adipose tissue is a significant site of E2 production in males but differ from a limited number of prior studies of young men in that we did not find lower T with increasing adiposity. Given E2's role in male hypothalamic-pituitary-gonadal function and complex interfaces with the immune system, these results have important implications for models of male life history as rates of overweight and obesity rise in populations around the world. Am. J. Hum. Biol. 26:376-383, 2014.

Original languageEnglish (US)
Pages (from-to)376-383
Number of pages8
JournalAmerican Journal of Human Biology
Issue number3
StatePublished - 2014

ASJC Scopus subject areas

  • Anthropology
  • Genetics
  • Ecology, Evolution, Behavior and Systematics
  • Anatomy


Dive into the research topics of 'Salivary estradiol and testosterone in filipino men: Diurnal patterns and relationships with adiposity'. Together they form a unique fingerprint.

Cite this