Salmon stanniocalcin and bovine parathyroid hormone have dissimilar actions on mammalian bone

Paula H. Stern*, Geetha Shankar, Robert C. Fargher, D. Harold Copp, Christine E. Milliken, Kanji J. Sato, David Goltzman, M. P.M. Herrmann‐Erlee

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Stanniocalcin (STC), a calcium‐regulating glycoprotein hormone isolated from the corpuscles of Stannius of salmon, was tested for effects on bone and calcium metabolism in mammalian species (rats and mice). STC generally failed to alter serum calcium of parathyroidectomized rats at concentrations equimolar with effective concentrations of parathyroid hormone (PTH). STC did not increase cAMP in ROS 17/2.8 or UMR‐108 osteosarcoma cells, OK kidney cells, fetal rat limb bones, or neonatal mouse calvariae, and similarly failed to increase urinary cAMP in rats. STC did not consistently stimulate resorption in any of the rodent bone culture systems, although variable resorptive responses were elicited in fetal mouse calvariae. The results indicate that this fish hormone has limited, if any, PTH‐like activity on calcium metabolism in mammalian systems.

Original languageEnglish (US)
Pages (from-to)1153-1159
Number of pages7
JournalJournal of Bone and Mineral Research
Volume6
Issue number11
DOIs
StatePublished - Nov 1991

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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    Stern, P. H., Shankar, G., Fargher, R. C., Copp, D. H., Milliken, C. E., Sato, K. J., Goltzman, D., & Herrmann‐Erlee, M. P. M. (1991). Salmon stanniocalcin and bovine parathyroid hormone have dissimilar actions on mammalian bone. Journal of Bone and Mineral Research, 6(11), 1153-1159. https://doi.org/10.1002/jbmr.5650061103