TY - JOUR
T1 - Salmon stanniocalcin and bovine parathyroid hormone have dissimilar actions on mammalian bone
AU - Stern, Paula H.
AU - Shankar, Geetha
AU - Fargher, Robert C.
AU - Copp, D. Harold
AU - Milliken, Christine E.
AU - Sato, Kanji J.
AU - Goltzman, David
AU - Herrmann‐Erlee, M. P.M.
PY - 1991/11
Y1 - 1991/11
N2 - Stanniocalcin (STC), a calcium‐regulating glycoprotein hormone isolated from the corpuscles of Stannius of salmon, was tested for effects on bone and calcium metabolism in mammalian species (rats and mice). STC generally failed to alter serum calcium of parathyroidectomized rats at concentrations equimolar with effective concentrations of parathyroid hormone (PTH). STC did not increase cAMP in ROS 17/2.8 or UMR‐108 osteosarcoma cells, OK kidney cells, fetal rat limb bones, or neonatal mouse calvariae, and similarly failed to increase urinary cAMP in rats. STC did not consistently stimulate resorption in any of the rodent bone culture systems, although variable resorptive responses were elicited in fetal mouse calvariae. The results indicate that this fish hormone has limited, if any, PTH‐like activity on calcium metabolism in mammalian systems.
AB - Stanniocalcin (STC), a calcium‐regulating glycoprotein hormone isolated from the corpuscles of Stannius of salmon, was tested for effects on bone and calcium metabolism in mammalian species (rats and mice). STC generally failed to alter serum calcium of parathyroidectomized rats at concentrations equimolar with effective concentrations of parathyroid hormone (PTH). STC did not increase cAMP in ROS 17/2.8 or UMR‐108 osteosarcoma cells, OK kidney cells, fetal rat limb bones, or neonatal mouse calvariae, and similarly failed to increase urinary cAMP in rats. STC did not consistently stimulate resorption in any of the rodent bone culture systems, although variable resorptive responses were elicited in fetal mouse calvariae. The results indicate that this fish hormone has limited, if any, PTH‐like activity on calcium metabolism in mammalian systems.
UR - http://www.scopus.com/inward/record.url?scp=0025724881&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025724881&partnerID=8YFLogxK
U2 - 10.1002/jbmr.5650061103
DO - 10.1002/jbmr.5650061103
M3 - Article
C2 - 1666805
AN - SCOPUS:0025724881
SN - 0884-0431
VL - 6
SP - 1153
EP - 1159
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 11
ER -
