SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction

Abdallah B. Diagne, Shuheng Li, Gregory A. Perkowski, Milan Mrksich*, Regan J. Thomson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.

Original languageEnglish (US)
Pages (from-to)658-662
Number of pages5
JournalACS Combinatorial Science
Volume17
Issue number11
DOIs
StatePublished - Nov 1 2015

Keywords

  • allenes
  • high-throughput experimentation
  • mass spectrometry
  • reaction optimization
  • self-assembled monolayers

ASJC Scopus subject areas

  • Chemistry(all)

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