SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction

Abdallah B. Diagne; Shuheng Li; Gregory A. Perkowski; Milan Mrksich; Regan J. Thomson

doi:10.1021/acscombsci.5b00131

SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction

Abdallah B. Diagne, Shuheng Li, Gregory A. Perkowski, Milan Mrksich^*, Regan J. Thomson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.

Original language	English (US)
Pages (from-to)	658-662
Number of pages	5
Journal	ACS Combinatorial Science
Volume	17
Issue number	11
DOIs	https://doi.org/10.1021/acscombsci.5b00131
State	Published - Nov 1 2015

Keywords

allenes
high-throughput experimentation
mass spectrometry
reaction optimization
self-assembled monolayers

ASJC Scopus subject areas

Chemistry(all)

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10.1021/acscombsci.5b00131

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abstract = "Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.",

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author = "Diagne, {Abdallah B.} and Shuheng Li and Perkowski, {Gregory A.} and Milan Mrksich and Thomson, {Regan J.}",

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AU - Diagne, Abdallah B.

AU - Li, Shuheng

AU - Perkowski, Gregory A.

AU - Mrksich, Milan

AU - Thomson, Regan J.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.

AB - Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.

KW - allenes

KW - high-throughput experimentation

KW - mass spectrometry

KW - reaction optimization

KW - self-assembled monolayers

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SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction

Abstract

Keywords

ASJC Scopus subject areas

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