Same-day 90Y radioembolization

implementing a new treatment paradigm

Ahmed Gabr, Joseph Ralph Kallini, Vanessa L. Gates, Ryan Hickey, Laura M Kulik, Kush R Desai, Bartley Thornburg, Karen Marshall, Krystina Salzig, Melissa Williams, Carlene del Castillo, Daniel R Ganger, Elias Hohlastos, Talia Baker, Robert J Lewandowski, Riad Salem*

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: To assess the feasibility of conducting pretreatment mesenteric angiography, coil embolization, 99mTc macroaggregated albumin (99mTc-MAA) scintigraphy, and 90Y radioembolization treatment in a single, same-day, combined outpatient encounter. Methods: This was a retrospective study of 78 patients treated during the period 2008 – 2015 who were managed in a single outpatient encounter under the guidance of the Interventional Radiology Department and The Nuclear Medicine Department. Pretreatment planning was performed by reviewing baseline imaging and estimated perfused liver volume bearing the tumor. The region of interest was estimated using 3-D software; this value was used for dosimetry planning. Maximum lung shunting fractions of 10 % for hepatocellular carcinoma and 5 % for liver metastases were assumed. Subsequently, hepatic angiography and 99mTc-MAA scintigraphy were performed followed by 90Y treatment in one outpatient encounter. Total in-room procedure time was recorded. Results: All patients underwent same-day angiography, 99mTc-MAA scintigraphy and 90Y radioembolization. Of the 78 patients, 16 received multiple segmental treatments to both lobes, 44 received treatment to the right lobe, and 18 received treatment to the left lobe. The median dose was 106 Gy. The median number of 90Y vials needed was two (range one to six). The median in-room time was 160 min (75 – 250 min). The residential status of the patients was as follows, 18 % (14/78) were local residents, 55 % (43/78) traveled from outside the city limits, 18 % (14/78) were from out-of-state, and 9 % (7/78) were resident abroad. Of the 78 patients, 61 (77 %) had hepatocellular carcinoma, and 17 (22 %) had liver metastases. The median lung dose was 3.5 Gy. Conclusion: This study demonstrated the feasibility of same-day 90Y evaluation and treatment while maintaining the principles of safe and effective 90Y infusion including tumoricidal dosimetry (lobar, segmentectomy), minimization of nontarget flow, and minimization of lung dose. This paradigm translates into expeditious cancer care and significant cost savings.

Original languageEnglish (US)
Pages (from-to)2353-2359
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume43
Issue number13
DOIs
StatePublished - Dec 1 2016

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Radionuclide Imaging
Albumins
Angiography
Outpatients
Liver
Lung
Hepatocellular Carcinoma
Neoplasm Metastasis
Therapeutics
Interventional Radiology
Segmental Mastectomy
Cost Savings
Nuclear Medicine
Feasibility Studies
Patient Rights
Tumor Burden
Software
Retrospective Studies
Neoplasms

Keywords

  • Lung shunting fraction
  • Radioembolization
  • Same-day

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Gabr, Ahmed ; Kallini, Joseph Ralph ; Gates, Vanessa L. ; Hickey, Ryan ; Kulik, Laura M ; Desai, Kush R ; Thornburg, Bartley ; Marshall, Karen ; Salzig, Krystina ; Williams, Melissa ; del Castillo, Carlene ; Ganger, Daniel R ; Hohlastos, Elias ; Baker, Talia ; Lewandowski, Robert J ; Salem, Riad. / Same-day 90Y radioembolization : implementing a new treatment paradigm. In: European Journal of Nuclear Medicine and Molecular Imaging. 2016 ; Vol. 43, No. 13. pp. 2353-2359.
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abstract = "Purpose: To assess the feasibility of conducting pretreatment mesenteric angiography, coil embolization, 99mTc macroaggregated albumin (99mTc-MAA) scintigraphy, and 90Y radioembolization treatment in a single, same-day, combined outpatient encounter. Methods: This was a retrospective study of 78 patients treated during the period 2008 – 2015 who were managed in a single outpatient encounter under the guidance of the Interventional Radiology Department and The Nuclear Medicine Department. Pretreatment planning was performed by reviewing baseline imaging and estimated perfused liver volume bearing the tumor. The region of interest was estimated using 3-D software; this value was used for dosimetry planning. Maximum lung shunting fractions of 10 {\%} for hepatocellular carcinoma and 5 {\%} for liver metastases were assumed. Subsequently, hepatic angiography and 99mTc-MAA scintigraphy were performed followed by 90Y treatment in one outpatient encounter. Total in-room procedure time was recorded. Results: All patients underwent same-day angiography, 99mTc-MAA scintigraphy and 90Y radioembolization. Of the 78 patients, 16 received multiple segmental treatments to both lobes, 44 received treatment to the right lobe, and 18 received treatment to the left lobe. The median dose was 106 Gy. The median number of 90Y vials needed was two (range one to six). The median in-room time was 160 min (75 – 250 min). The residential status of the patients was as follows, 18 {\%} (14/78) were local residents, 55 {\%} (43/78) traveled from outside the city limits, 18 {\%} (14/78) were from out-of-state, and 9 {\%} (7/78) were resident abroad. Of the 78 patients, 61 (77 {\%}) had hepatocellular carcinoma, and 17 (22 {\%}) had liver metastases. The median lung dose was 3.5 Gy. Conclusion: This study demonstrated the feasibility of same-day 90Y evaluation and treatment while maintaining the principles of safe and effective 90Y infusion including tumoricidal dosimetry (lobar, segmentectomy), minimization of nontarget flow, and minimization of lung dose. This paradigm translates into expeditious cancer care and significant cost savings.",
keywords = "Lung shunting fraction, Radioembolization, Same-day",
author = "Ahmed Gabr and Kallini, {Joseph Ralph} and Gates, {Vanessa L.} and Ryan Hickey and Kulik, {Laura M} and Desai, {Kush R} and Bartley Thornburg and Karen Marshall and Krystina Salzig and Melissa Williams and {del Castillo}, Carlene and Ganger, {Daniel R} and Elias Hohlastos and Talia Baker and Lewandowski, {Robert J} and Riad Salem",
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Gabr, A, Kallini, JR, Gates, VL, Hickey, R, Kulik, LM, Desai, KR, Thornburg, B, Marshall, K, Salzig, K, Williams, M, del Castillo, C, Ganger, DR, Hohlastos, E, Baker, T, Lewandowski, RJ & Salem, R 2016, 'Same-day 90Y radioembolization: implementing a new treatment paradigm', European Journal of Nuclear Medicine and Molecular Imaging, vol. 43, no. 13, pp. 2353-2359. https://doi.org/10.1007/s00259-016-3438-x

Same-day 90Y radioembolization : implementing a new treatment paradigm. / Gabr, Ahmed; Kallini, Joseph Ralph; Gates, Vanessa L.; Hickey, Ryan; Kulik, Laura M; Desai, Kush R; Thornburg, Bartley; Marshall, Karen; Salzig, Krystina; Williams, Melissa; del Castillo, Carlene; Ganger, Daniel R; Hohlastos, Elias; Baker, Talia; Lewandowski, Robert J; Salem, Riad.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 43, No. 13, 01.12.2016, p. 2353-2359.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Same-day 90Y radioembolization

T2 - implementing a new treatment paradigm

AU - Gabr, Ahmed

AU - Kallini, Joseph Ralph

AU - Gates, Vanessa L.

AU - Hickey, Ryan

AU - Kulik, Laura M

AU - Desai, Kush R

AU - Thornburg, Bartley

AU - Marshall, Karen

AU - Salzig, Krystina

AU - Williams, Melissa

AU - del Castillo, Carlene

AU - Ganger, Daniel R

AU - Hohlastos, Elias

AU - Baker, Talia

AU - Lewandowski, Robert J

AU - Salem, Riad

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Purpose: To assess the feasibility of conducting pretreatment mesenteric angiography, coil embolization, 99mTc macroaggregated albumin (99mTc-MAA) scintigraphy, and 90Y radioembolization treatment in a single, same-day, combined outpatient encounter. Methods: This was a retrospective study of 78 patients treated during the period 2008 – 2015 who were managed in a single outpatient encounter under the guidance of the Interventional Radiology Department and The Nuclear Medicine Department. Pretreatment planning was performed by reviewing baseline imaging and estimated perfused liver volume bearing the tumor. The region of interest was estimated using 3-D software; this value was used for dosimetry planning. Maximum lung shunting fractions of 10 % for hepatocellular carcinoma and 5 % for liver metastases were assumed. Subsequently, hepatic angiography and 99mTc-MAA scintigraphy were performed followed by 90Y treatment in one outpatient encounter. Total in-room procedure time was recorded. Results: All patients underwent same-day angiography, 99mTc-MAA scintigraphy and 90Y radioembolization. Of the 78 patients, 16 received multiple segmental treatments to both lobes, 44 received treatment to the right lobe, and 18 received treatment to the left lobe. The median dose was 106 Gy. The median number of 90Y vials needed was two (range one to six). The median in-room time was 160 min (75 – 250 min). The residential status of the patients was as follows, 18 % (14/78) were local residents, 55 % (43/78) traveled from outside the city limits, 18 % (14/78) were from out-of-state, and 9 % (7/78) were resident abroad. Of the 78 patients, 61 (77 %) had hepatocellular carcinoma, and 17 (22 %) had liver metastases. The median lung dose was 3.5 Gy. Conclusion: This study demonstrated the feasibility of same-day 90Y evaluation and treatment while maintaining the principles of safe and effective 90Y infusion including tumoricidal dosimetry (lobar, segmentectomy), minimization of nontarget flow, and minimization of lung dose. This paradigm translates into expeditious cancer care and significant cost savings.

AB - Purpose: To assess the feasibility of conducting pretreatment mesenteric angiography, coil embolization, 99mTc macroaggregated albumin (99mTc-MAA) scintigraphy, and 90Y radioembolization treatment in a single, same-day, combined outpatient encounter. Methods: This was a retrospective study of 78 patients treated during the period 2008 – 2015 who were managed in a single outpatient encounter under the guidance of the Interventional Radiology Department and The Nuclear Medicine Department. Pretreatment planning was performed by reviewing baseline imaging and estimated perfused liver volume bearing the tumor. The region of interest was estimated using 3-D software; this value was used for dosimetry planning. Maximum lung shunting fractions of 10 % for hepatocellular carcinoma and 5 % for liver metastases were assumed. Subsequently, hepatic angiography and 99mTc-MAA scintigraphy were performed followed by 90Y treatment in one outpatient encounter. Total in-room procedure time was recorded. Results: All patients underwent same-day angiography, 99mTc-MAA scintigraphy and 90Y radioembolization. Of the 78 patients, 16 received multiple segmental treatments to both lobes, 44 received treatment to the right lobe, and 18 received treatment to the left lobe. The median dose was 106 Gy. The median number of 90Y vials needed was two (range one to six). The median in-room time was 160 min (75 – 250 min). The residential status of the patients was as follows, 18 % (14/78) were local residents, 55 % (43/78) traveled from outside the city limits, 18 % (14/78) were from out-of-state, and 9 % (7/78) were resident abroad. Of the 78 patients, 61 (77 %) had hepatocellular carcinoma, and 17 (22 %) had liver metastases. The median lung dose was 3.5 Gy. Conclusion: This study demonstrated the feasibility of same-day 90Y evaluation and treatment while maintaining the principles of safe and effective 90Y infusion including tumoricidal dosimetry (lobar, segmentectomy), minimization of nontarget flow, and minimization of lung dose. This paradigm translates into expeditious cancer care and significant cost savings.

KW - Lung shunting fraction

KW - Radioembolization

KW - Same-day

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