Sarcoid encephalopathy with diffuse inflammation and focal hydrocephalus shown by sequential ct

Sam U. Ho, Richard A. Berenberg, Kwang S. Kim, Mauro C. Dal Canto

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Sequential computerized tomography (CT) was performed on a patient with seizures and an organic mental syndrome. Cerebral sarcoidosis was subsequently diagnosed on the basis of nonca-seating granulomas in three organ systems. Cranial nerve palsies, hypothalamic dysfunction, and widespread disease were absent. An unusual neuroradiologic sequence of events indicated focal and asymmetric hydrocephalus, mass effect, ependymitis, diffuse breakdown of the blood- brain barrier, and periventricular white matter destruction. These findings have not been previously described together in a patient with sarcoid. With the advent of noninvasive CT, it is possible to perform serial investigations of encephalopathies of obscure origin. Findings similar to those in the present case should prompt a thorough search for subclinical systemic involvement by sarcoid.

Original languageEnglish (US)
Pages (from-to)1161-1165
Number of pages5
JournalNeurology
Volume29
Issue number8
DOIs
StatePublished - Aug 1979

ASJC Scopus subject areas

  • Clinical Neurology

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