Sarcomere length operating range of vertebrate muscles during movement

Thomas J. Burkholder, Richard L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

194 Scopus citations

Abstract

The force generated by skeletal muscle varies with sarcomere length and velocity. An understanding of the sarcomere length changes that occur during movement provides insights into the physiological importance of this relationship and may provide insights into the design of certain muscle/joint combinations. The purpose of this review is to summarize and analyze the available literature regarding published sarcomere length operating ranges reported for various species. Our secondary purpose is to apply analytical techniques to determine whether generalizations can be made regarding the 'normal' sarcomere length operating range of skeletal muscle. The analysis suggests that many muscles operate over a narrow range of sarcomere lengths, covering 94±13 % of optimal sarcomere length. Sarcomere length measurements are found to be systematically influenced by the rigor state and methods used to make these measurements.

Original languageEnglish (US)
Pages (from-to)1529-1536
Number of pages8
JournalJournal of Experimental Biology
Volume204
Issue number9
StatePublished - 2001

Keywords

  • Actin
  • Locomotion
  • Muscle design
  • Myofilament
  • Myosin
  • Sarcomere

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

Fingerprint Dive into the research topics of 'Sarcomere length operating range of vertebrate muscles during movement'. Together they form a unique fingerprint.

Cite this