SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells

Keyphrases

• Alveolar Epithelial Cells 100%
• Upstream Open Reading Frame (uORF) 100%
• Intracellular Aggregation 100%
• Antiviral Gene Expression 100%
• COVID-19 100%
• ORF8 Protein 62%
• Lung Epithelial Cells 37%
• Viral Infection 12%
• Epithelial Cell Proliferation 12%
• Severe Acute Respiratory Syndrome Coronavirus 2 Infection 12%
• Antiviral Molecules 12%
• Bioinformatics Analysis 6%
• Cell Behavior 6%
• Cell-to-cell 6%
• Cell Culture 6%
• Lung 6%
• Lung Injury 6%
• Cellular Processes 6%
• In Silico 6%
• Ectopic Expression 6%
• Cell Cycle Progression 6%
• Live Imaging 6%
• Antiviral Immunity 6%
• Antiviral Immune Response 6%
• Cellular Distribution 6%
• COVID-19 Patients 6%
• Accessory Protein 6%
• Basal Expression 6%
• 2-form 6%
• Pathogenic Effects 6%
• Terminal Residue 6%
• Nuclear Compartments 6%
• Antiviral Protein 6%
• Immunofluorescent Staining 6%
• Viral Accessory Proteins 6%
• Aggregation Characteristics 6%
• DHX58 6%
• ZBP1 6%
• Lung Tissue Damage 6%
• Post-COVID Symptoms 6%

Medicine and Dentistry

• Gene Expression 100%
• Epithelial Cell 100%
• Antivirus Agent 100%
• Severe Acute Respiratory Syndrome Coronavirus 2 100%
• Lung 100%
• Open Reading Frame 100%
• Infection 17%
• COVID-19 17%
• Cell Proliferation 11%
• Virus Infection 11%
• Cytosol 5%
• Cell Function 5%
• Amino Terminal Sequence 5%
• Innate Immunity 5%
• In Silico 5%
• Tissue Injury 5%
• Cell Cycle Progression 5%
• Immunofluorescence Test 5%
• Antiviral Immunity 5%
• Antiviral Protein 5%
• Cell Culture 5%
• Ectopic Expression 5%
• Diseases 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Antivirus Agent 100%
• SARS Coronavirus 100%
• Infection 17%
• Virus Infection 11%
• Cellular Processes 5%
• Cell Culture 5%
• Tissue Injury 5%
• Viral Protein 5%
• Diseases 5%