Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000

Timothy C. Wang, Nicolaas A. Vermeulen, In Soo Kim, Alex B.F. Martinson, J. Fraser Stoddart, Joseph T. Hupp, Omar K. Farha

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

The synthesis of NU-1000, a highly robust mesoporous (containing pores >2 nm) metal-organic framework (MOF), can be conducted efficiently on a multigram scale from inexpensive starting materials. Tetrabromopyrene and (4-(ethoxycarbonyl)phenyl)boronic acid can easily be coupled to prepare the requisite organic strut with four metal-binding sites in the form of four carboxylic acids, while zirconyl chloride octahydrate is used as a precursor for the well-defined metal oxide clusters. NU-1000 has been reported as an excellent candidate for the separation of gases, and it is a versatile scaffold for heterogeneous catalysis. In particular, it is ideal for the catalytic deactivation of nerve agents, and it shows great promise as a new generic platform for a wide range of applications. Multiple post-synthetic modification protocols have been developed using NU-1000 as the parent material, making it a potentially useful scaffold for several catalytic applications. The procedure for the preparation of NU-1000 can be scaled up reliably, and it is suitable for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg-2.5 g of NU-1000. The entire synthesis is performed without purification by column chromatography and can be completed within 10 d.

Original languageEnglish (US)
Pages (from-to)149-162
Number of pages14
JournalNature Protocols
Volume11
Issue number1
DOIs
StatePublished - Jan 3 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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