Investigators have modeled the hydraulic permeability of hyaluronic acid using a fiber matrix model such as developed by J. Happel. However, C. R. Ethier found that the concentration dependence of the sedimentation rate of hyaluronic acid is inconsistent with the predictions of the fiber matrix model and with perfusion measurements of the hydraulic permeability. These discrepancies are investigated and a tentative explanation provided. The discrepancy found between the predictions of the fiber matrix model and the results of perfusion studies may be due to concentration polarization. This process was modeled and examined experimentally. The experimental results are in qualitative agreement with the theory.
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