A tumorigenic human cell line was derived from a patient with metastatic melanoma. Cells were treated with adriamycin or actinomycin D in order to assess morphological alterations induced by these anticancer agents using SEM and TEM. TEM of colonies treated in soft agar for 24 hours with either 1. 0 mu g/ml adriamycin or 1. 0 mu g/ml actinomycin D showed major morphological effects identified by increased cytoplasmic vacuolization and nuclear disintegration.
|Original language||English (US)|
|Number of pages||13|
|Journal||Scanning Electron Microscopy|
|Issue number||pt 2|
|State||Published - 1983|
ASJC Scopus subject areas
- Control and Systems Engineering