SCANNING AND TRANSMISSION ELECTRON MICROSCOPIC EVALUATION OF HUMAN MELANOMA CELLS TREATED WITH ADRIAMYCIN AND ACTINOMYCIN D.

B. Persky*, E. M. Peters, K. R. Gehlsen, J. M. Sorrentino, F. L. Meyskens, M. J.C. Hendrix

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A tumorigenic human cell line was derived from a patient with metastatic melanoma. Cells were treated with adriamycin or actinomycin D in order to assess morphological alterations induced by these anticancer agents using SEM and TEM. TEM of colonies treated in soft agar for 24 hours with either 1. 0 mu g/ml adriamycin or 1. 0 mu g/ml actinomycin D showed major morphological effects identified by increased cytoplasmic vacuolization and nuclear disintegration.

Original languageEnglish (US)
Pages (from-to)983-995
Number of pages13
JournalScanning Electron Microscopy
Volumev
Issue numberpt 2
StatePublished - 1983

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Biophysics

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