Scene-selective coding by single neurons in the human parahippocampal cortex

Florian Mormann; Simon Kornblith; Moran Cerf; Matias J. Ison; Alexander Kraskov; Michelle Tran; Simeon Knieling; Rodrigo Quian Quiroga; Christof Koch; Itzhak Fried

doi:10.1073/pnas.1608159113

Scene-selective coding by single neurons in the human parahippocampal cortex

Florian Mormann^*, Simon Kornblith, Moran Cerf, Matias J. Ison, Alexander Kraskov, Michelle Tran, Simeon Knieling, Rodrigo Quian Quiroga, Christof Koch, Itzhak Fried

^*Corresponding author for this work

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Abstract

Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of single parahippocampal neurons remains largely unknown. In this study, we analyzed responses from 630 parahippocampal neurons in 24 neurosurgical patients during visual stimulus presentation. We found a spatially clustered subpopulation of sceneselective units with an associated event-related field potential. These units form a population code that is more distributed for scenes than for other stimulus categories, and less sparse than elsewhere in the medial temporal lobe. Our electrophysiological findings provide insight into how individual units give rise to the population response observed with functional imaging in the parahippocampal place area.

Original language	English (US)
Pages (from-to)	1153-1158
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	114
Issue number	5
DOIs	https://doi.org/10.1073/pnas.1608159113
State	Published - Jan 31 2017

Funding

This research was supported by grants from the Volkswagen Foundation (Lichtenberg Program), the German Research Council (DFG MO930/4-1 and SFB 1089), the National Institute of Neurological Disorders and Stroke, the G. Harold and Leila Y. Mathers Foundation, the Gimbel Discovery Fund, the Dana Foundation, the Human Frontiers Science Program, and a National Science Foundation Graduate Research Fellowship (to S. Kornblith).

Keywords

Electrophysiology
Population code
Scene selectivity
Single units

ASJC Scopus subject areas

General

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10.1073/pnas.1608159113

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abstract = "Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of single parahippocampal neurons remains largely unknown. In this study, we analyzed responses from 630 parahippocampal neurons in 24 neurosurgical patients during visual stimulus presentation. We found a spatially clustered subpopulation of sceneselective units with an associated event-related field potential. These units form a population code that is more distributed for scenes than for other stimulus categories, and less sparse than elsewhere in the medial temporal lobe. Our electrophysiological findings provide insight into how individual units give rise to the population response observed with functional imaging in the parahippocampal place area.",

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AU - Tran, Michelle

AU - Knieling, Simeon

AU - Quiroga, Rodrigo Quian

AU - Koch, Christof

AU - Fried, Itzhak

N1 - Funding Information: This research was supported by grants from the Volkswagen Foundation (Lichtenberg Program), the German Research Council (DFG MO930/4-1 and SFB 1089), the National Institute of Neurological Disorders and Stroke, the G. Harold and Leila Y. Mathers Foundation, the Gimbel Discovery Fund, the Dana Foundation, the Human Frontiers Science Program, and a National Science Foundation Graduate Research Fellowship (to S. Kornblith).

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N2 - Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of single parahippocampal neurons remains largely unknown. In this study, we analyzed responses from 630 parahippocampal neurons in 24 neurosurgical patients during visual stimulus presentation. We found a spatially clustered subpopulation of sceneselective units with an associated event-related field potential. These units form a population code that is more distributed for scenes than for other stimulus categories, and less sparse than elsewhere in the medial temporal lobe. Our electrophysiological findings provide insight into how individual units give rise to the population response observed with functional imaging in the parahippocampal place area.

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Scene-selective coding by single neurons in the human parahippocampal cortex

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