SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?

Medha Priyadarshini; Barton Wicksteed; Gary E. Schiltz; Annette Gilchrist; Brian T. Layden

doi:10.1016/j.tem.2016.03.011

SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?

Medha Priyadarshini, Barton Wicksteed, Gary E. Schiltz, Annette Gilchrist, Brian T. Layden^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Nutrient sensing receptors are key metabolic mediators of responses to dietary and endogenously derived nutrients. These receptors are largely G-protein-coupled receptors (GPCRs) and many are gaining significant interest as drug targets with a potential therapeutic role in metabolic diseases. A distinct subclass of nutrient sensing GPCRs, two short chain fatty acid (SCFA) receptors (FFA2 and FFA3) are uniquely responsive to gut microbiota derived nutrients (such as acetate, propionate, and butyrate). Pharmacological, molecular, and genetic studies have investigated their role in organismal glucose metabolism and recently in pancreatic β cell biology. Here, we summarize the present knowledge on the role of these receptors as metabolic sensors in β cell function and physiology, revealing new therapeutic opportunities for type 2 diabetes.

Original language	English (US)
Pages (from-to)	653-664
Number of pages	12
Journal	Trends in Endocrinology and Metabolism
Volume	27
Issue number	9
DOIs	https://doi.org/10.1016/j.tem.2016.03.011
State	Published - 2016

Keywords

FFA2
FFA3
gut microbiota
insulin secretion
short chain fatty acids
β cell mass

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2016.03.011

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title = "SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?",

abstract = "Nutrient sensing receptors are key metabolic mediators of responses to dietary and endogenously derived nutrients. These receptors are largely G-protein-coupled receptors (GPCRs) and many are gaining significant interest as drug targets with a potential therapeutic role in metabolic diseases. A distinct subclass of nutrient sensing GPCRs, two short chain fatty acid (SCFA) receptors (FFA2 and FFA3) are uniquely responsive to gut microbiota derived nutrients (such as acetate, propionate, and butyrate). Pharmacological, molecular, and genetic studies have investigated their role in organismal glucose metabolism and recently in pancreatic β cell biology. Here, we summarize the present knowledge on the role of these receptors as metabolic sensors in β cell function and physiology, revealing new therapeutic opportunities for type 2 diabetes.",

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author = "Medha Priyadarshini and Barton Wicksteed and Schiltz, {Gary E.} and Annette Gilchrist and Layden, {Brian T.}",

note = "Funding Information: B.T.L. is supported by the National Institutes of Health under award number, R01DK104927-01A1, The University of Chicago DR&TC (P30DK020595), and Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Career Development (Grant no. 1IK2BX001587-01). M.P. is supported by an American Heart Association postdoctoral fellowship (#15POST22410016). A part of this work was performed by the Northwestern University Medicinal and Synthetic Chemistry Core (ChemCore) at the Center for Molecular Innovation and Drug Discovery (CMIDD), which is funded by the Chicago Biomedical Consortium with support from the Searle Funds at the Chicago Community Trust. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

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language = "English (US)",

volume = "27",

pages = "653--664",

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AU - Wicksteed, Barton

AU - Schiltz, Gary E.

AU - Gilchrist, Annette

AU - Layden, Brian T.

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PY - 2016

Y1 - 2016

N2 - Nutrient sensing receptors are key metabolic mediators of responses to dietary and endogenously derived nutrients. These receptors are largely G-protein-coupled receptors (GPCRs) and many are gaining significant interest as drug targets with a potential therapeutic role in metabolic diseases. A distinct subclass of nutrient sensing GPCRs, two short chain fatty acid (SCFA) receptors (FFA2 and FFA3) are uniquely responsive to gut microbiota derived nutrients (such as acetate, propionate, and butyrate). Pharmacological, molecular, and genetic studies have investigated their role in organismal glucose metabolism and recently in pancreatic β cell biology. Here, we summarize the present knowledge on the role of these receptors as metabolic sensors in β cell function and physiology, revealing new therapeutic opportunities for type 2 diabetes.

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KW - short chain fatty acids

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SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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