Schizophrenia: age at onset, gender and familial risk

A. E. Pulver*, C. H. Brown, P. Wolyniec, J. McGrath, D. Tam, L. Adler, W. T. Carpenter, B. Childs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

In a family history study of 366 schizophrenic probands and their 1851 first‐degree relatives, we found a relationship between age at onset of psychosis in the male probands and the risk for schizophrenia in their relatives. The relatives of male schizophrenic probands whose onset of psychosis occurred when they were younger than 17 years of age had an increased risk of schizophrenia when compared with the relatives of male probands with an age at onset greater than 17. We did not find an association between age at onset of psychosis in the female probands and familial risk. Cox proportional hazards models permitted us to examine the relationship between age at onset of psychosis in the probands and familial risk while controlling for possible confounding effects.

Original languageEnglish (US)
Pages (from-to)344-351
Number of pages8
JournalActa Psychiatrica Scandinavica
Volume82
Issue number5
DOIs
StatePublished - Nov 1990

Funding

Keywords

  • Key words
  • age at onset
  • family
  • schizophrenia
  • sex difference

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'Schizophrenia: age at onset, gender and familial risk'. Together they form a unique fingerprint.

Cite this