Schizophrenia and the Brain

M. Marsel Mesulam*

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

39 Scopus citations


Schizophrenia is a devastating disease of unknown cause. Its protean symptoms range from a pervasive blunting of affect, thought, and socialization, to florid hallucinations and delusions. Its characteristic onset during adolescence and young adulthood interferes with the most productive period of life and results in prolonged suffering. Even with the most up-to-date management, about half the patients have chronic deterioration, and the rest a more episodic course. The worldwide prevalence is approximately 1 percent. In the United States alone, the cost to society runs from $10 to $20 billion yearly.1 There have been two major advances in this field recently…

Original languageEnglish (US)
Pages (from-to)842-845
Number of pages4
JournalNew England Journal of Medicine
Issue number12
StatePublished - Mar 22 1990

ASJC Scopus subject areas

  • Medicine(all)

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