Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought

Peter Rabins, Brian S. Appleby, Jason Brandt, Mahlon R. DeLong, Laura B. Dunn, Loes Gabriëls, Benjamin D. Greenberg, Suzanne N. Haber, Paul E. Holtzheimer, Zoltan Mari, Helen S. Mayberg, Evelyn McCann, Sallie P. Mink, Steven Rasmussen, Thomas E. Schlaepfer, Dorothy E. Vawter, Jerrold L. Vitek, John Walkup, Debra J.H. Mathews

Research output: Contribution to journalReview article

136 Scopus citations

Abstract

Context: A 2-day consensus conference was held to examine scientific and ethical issues in the application of deep brain stimulation for treating mood and behavioral disorders, such as major depression, obsessivecompulsive disorder, and Tourette syndrome. Objectives: The primary objectives of the conference were to (1) establish consensus among participants about the design of future clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and (2) develop standards for the protection of human subjects participating in such studies. Results: Conference participants identified 16 key points for guiding research in this growing field. Conclusions: The adoption of the described guidelines would help to protect the safety and rights of research subjects who participate in clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and have further potential to benefit other stakeholders in the research process, including clinical researchers and device manufactures. That said, the adoption of the guidelines will require broad and substantial commitment from many of these same stakeholders.

Original languageEnglish (US)
Pages (from-to)931-937
Number of pages7
JournalArchives of general psychiatry
Volume66
Issue number9
DOIs
StatePublished - Sep 1 2009

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Rabins, P., Appleby, B. S., Brandt, J., DeLong, M. R., Dunn, L. B., Gabriëls, L., Greenberg, B. D., Haber, S. N., Holtzheimer, P. E., Mari, Z., Mayberg, H. S., McCann, E., Mink, S. P., Rasmussen, S., Schlaepfer, T. E., Vawter, D. E., Vitek, J. L., Walkup, J., & Mathews, D. J. H. (2009). Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought. Archives of general psychiatry, 66(9), 931-937. https://doi.org/10.1001/archgenpsychiatry.2009.113