Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop

Herman A. Taylor; Toren Finkel; Yunling Gao; Scott W. Ballinger; Rebecca Campo; Rong Chen; Shu Hui Chen; Karina Davidson; M. Luisa Iruela-Arispe; Cashell Jaquish; Nathan K. LeBrasseur; Michelle C. Odden; George J. Papanicolaou; Martin Picard; Pothur Srinivas; Olga Tjurmina; Michael Wolz; Zorina S. Galis

doi:10.1096/fj.202201407R

Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop

Herman A. Taylor, Toren Finkel, Yunling Gao^*, Scott W. Ballinger, Rebecca Campo, Rong Chen, Shu Hui Chen, Karina Davidson, M. Luisa Iruela-Arispe, Cashell Jaquish, Nathan K. LeBrasseur, Michelle C. Odden, George J. Papanicolaou, Martin Picard, Pothur Srinivas, Olga Tjurmina, Michael Wolz, Zorina S. Galis

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Exposure of biological systems to acute or chronic insults triggers a host of molecular and physiological responses to either tolerate, adapt, or fully restore homeostasis; these responses constitute the hallmarks of resilience. Given the many facets, dimensions, and discipline-specific focus, gaining a shared understanding of “resilience” has been identified as a priority for supporting advances in cardiovascular health. This report is based on the working definition: “Resilience is the ability of living systems to successfully maintain or return to homeostasis in response to physical, molecular, individual, social, societal, or environmental stressors or challenges,” developed after considering many factors contributing to cardiovascular resilience through deliberations of multidisciplinary experts convened by the National Heart, Lung, and Blood Institute during a workshop entitled: “Enhancing Resilience for Cardiovascular Health and Wellness.” Some of the main emerging themes that support the possibility of enhancing resilience for cardiovascular health include optimal energy management and substrate diversity, a robust immune system that safeguards tissue homeostasis, and social and community support. The report also highlights existing research challenges, along with immediate and long-term opportunities for resilience research. Certain immediate opportunities identified are based on leveraging existing high-dimensional data from longitudinal clinical studies to identify vascular resilience measures, create a ‘resilience index,’ and adopt a life-course approach. Long-term opportunities include developing quantitative cell/organ/system/community models to identify resilience factors and mechanisms at these various levels, designing experimental and clinical interventions that specifically assess resilience, adopting global sharing of resilience-related data, and cross-domain training of next-generation researchers in this field.

Original language	English (US)
Article number	e22639
Journal	FASEB Journal
Volume	36
Issue number	12
DOIs	https://doi.org/10.1096/fj.202201407R
State	Published - Dec 2022

Funding

The workshop Enhancing Resilience for Cardiovascular Health and Wellness was supported by the NHLBI, NIH. Dr. Taylor was supported by AHA grant 0000031288 and NIH grant P50 HL117929. Dr. Finkel was supported by NIH grant P30 AG024827; R01 HL14266; R01 HL142589 and U54 AG075931. Dr. Chen was supported by NIH grant UG3 TR004040. Dr. LeBrasseur was supported by NIH grants R01 AG53832, U54 AG44170, and P01 AG62413. Dr. Ballinger was supported by NIH grants R01 HL103859 and T32 HL007918. Dr. Iruela-Arispe was supported by NIH grants R35 HL140014. Dr. Odden was supported by NIH grants R21 HL135195, R01 AG046206, R01 AG062568, R01 AG071019, R01 HL151564. Dr. Davidson was supported by NIH grants R24 AG064191 and R01 LM012836. Dr. Picard was supported by NIH grants R01 MH119336, R01 MH122706, R01 AG066828, R21 MH123927, and the Wharton Fund. The authors thank their colleague Dr. Charles Nicholas Serhan (Brigham & Women's Health, Harvard University) for assisting with workshop presentations and Drs. Kathleen Fenton and Laurie Donze (NHLBI) for critical reading and suggestions for the manuscript. The workshop was supported by the NHLBI, NIH. Dr. Taylor was supported by AHA grant 0000031288 and NIH grant P50 HL117929. Dr. Finkel was supported by NIH grant P30 AG024827; R01 HL14266; R01 HL142589 and U54 AG075931. Dr. Chen was supported by NIH grant UG3 TR004040. Dr. LeBrasseur was supported by NIH grants R01 AG53832, U54 AG44170, and P01 AG62413. Dr. Ballinger was supported by NIH grants R01 HL103859 and T32 HL007918. Dr. Iruela‐Arispe was supported by NIH grants R35 HL140014. Dr. Odden was supported by NIH grants R21 HL135195, R01 AG046206, R01 AG062568, R01 AG071019, R01 HL151564. Dr. Davidson was supported by NIH grants R24 AG064191 and R01 LM012836. Dr. Picard was supported by NIH grants R01 MH119336, R01 MH122706, R01 AG066828, R21 MH123927, and the Wharton Fund. The authors thank their colleague Dr. Charles Nicholas Serhan (Brigham & Women's Health, Harvard University) for assisting with workshop presentations and Drs. Kathleen Fenton and Laurie Donze (NHLBI) for critical reading and suggestions for the manuscript. Enhancing Resilience for Cardiovascular Health and Wellness

Keywords

adaptation
aging
cardiovascular disease
cardiovascular health
genetic plasticity
health disparities
homeostasis
resilience
stress

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1096/fj.202201407R

Cite this

Taylor, H. A., Finkel, T., Gao, Y., Ballinger, S. W., Campo, R., Chen, R., Chen, S. H., Davidson, K., Iruela-Arispe, M. L., Jaquish, C., LeBrasseur, N. K., Odden, M. C., Papanicolaou, G. J., Picard, M., Srinivas, P., Tjurmina, O., Wolz, M., & Galis, Z. S. (2022). Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop. FASEB Journal, 36(12), Article e22639. https://doi.org/10.1096/fj.202201407R

@article{a3d1bb23814e47eba94d6a3e0f9a3607,

title = "Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop",

abstract = "Exposure of biological systems to acute or chronic insults triggers a host of molecular and physiological responses to either tolerate, adapt, or fully restore homeostasis; these responses constitute the hallmarks of resilience. Given the many facets, dimensions, and discipline-specific focus, gaining a shared understanding of “resilience” has been identified as a priority for supporting advances in cardiovascular health. This report is based on the working definition: “Resilience is the ability of living systems to successfully maintain or return to homeostasis in response to physical, molecular, individual, social, societal, or environmental stressors or challenges,” developed after considering many factors contributing to cardiovascular resilience through deliberations of multidisciplinary experts convened by the National Heart, Lung, and Blood Institute during a workshop entitled: “Enhancing Resilience for Cardiovascular Health and Wellness.” Some of the main emerging themes that support the possibility of enhancing resilience for cardiovascular health include optimal energy management and substrate diversity, a robust immune system that safeguards tissue homeostasis, and social and community support. The report also highlights existing research challenges, along with immediate and long-term opportunities for resilience research. Certain immediate opportunities identified are based on leveraging existing high-dimensional data from longitudinal clinical studies to identify vascular resilience measures, create a {\textquoteleft}resilience index,{\textquoteright} and adopt a life-course approach. Long-term opportunities include developing quantitative cell/organ/system/community models to identify resilience factors and mechanisms at these various levels, designing experimental and clinical interventions that specifically assess resilience, adopting global sharing of resilience-related data, and cross-domain training of next-generation researchers in this field.",

keywords = "adaptation, aging, cardiovascular disease, cardiovascular health, genetic plasticity, health disparities, homeostasis, resilience, stress",

author = "Taylor, {Herman A.} and Toren Finkel and Yunling Gao and Ballinger, {Scott W.} and Rebecca Campo and Rong Chen and Chen, {Shu Hui} and Karina Davidson and Iruela-Arispe, {M. Luisa} and Cashell Jaquish and LeBrasseur, {Nathan K.} and Odden, {Michelle C.} and Papanicolaou, {George J.} and Martin Picard and Pothur Srinivas and Olga Tjurmina and Michael Wolz and Galis, {Zorina S.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.",

year = "2022",

month = dec,

doi = "10.1096/fj.202201407R",

language = "English (US)",

volume = "36",

journal = "FASEB Journal",

issn = "0892-6638",

publisher = "John Wiley & Sons Inc.",

number = "12",

}

Taylor, HA, Finkel, T, Gao, Y, Ballinger, SW, Campo, R, Chen, R, Chen, SH, Davidson, K, Iruela-Arispe, ML, Jaquish, C, LeBrasseur, NK, Odden, MC, Papanicolaou, GJ, Picard, M, Srinivas, P, Tjurmina, O, Wolz, M & Galis, ZS 2022, 'Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop', FASEB Journal, vol. 36, no. 12, e22639. https://doi.org/10.1096/fj.202201407R

TY - JOUR

T1 - Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop

AU - Taylor, Herman A.

AU - Finkel, Toren

AU - Gao, Yunling

AU - Ballinger, Scott W.

AU - Campo, Rebecca

AU - Chen, Rong

AU - Chen, Shu Hui

AU - Davidson, Karina

AU - Iruela-Arispe, M. Luisa

AU - Jaquish, Cashell

AU - LeBrasseur, Nathan K.

AU - Odden, Michelle C.

AU - Papanicolaou, George J.

AU - Picard, Martin

AU - Srinivas, Pothur

AU - Tjurmina, Olga

AU - Wolz, Michael

AU - Galis, Zorina S.

PY - 2022/12

Y1 - 2022/12

N2 - Exposure of biological systems to acute or chronic insults triggers a host of molecular and physiological responses to either tolerate, adapt, or fully restore homeostasis; these responses constitute the hallmarks of resilience. Given the many facets, dimensions, and discipline-specific focus, gaining a shared understanding of “resilience” has been identified as a priority for supporting advances in cardiovascular health. This report is based on the working definition: “Resilience is the ability of living systems to successfully maintain or return to homeostasis in response to physical, molecular, individual, social, societal, or environmental stressors or challenges,” developed after considering many factors contributing to cardiovascular resilience through deliberations of multidisciplinary experts convened by the National Heart, Lung, and Blood Institute during a workshop entitled: “Enhancing Resilience for Cardiovascular Health and Wellness.” Some of the main emerging themes that support the possibility of enhancing resilience for cardiovascular health include optimal energy management and substrate diversity, a robust immune system that safeguards tissue homeostasis, and social and community support. The report also highlights existing research challenges, along with immediate and long-term opportunities for resilience research. Certain immediate opportunities identified are based on leveraging existing high-dimensional data from longitudinal clinical studies to identify vascular resilience measures, create a ‘resilience index,’ and adopt a life-course approach. Long-term opportunities include developing quantitative cell/organ/system/community models to identify resilience factors and mechanisms at these various levels, designing experimental and clinical interventions that specifically assess resilience, adopting global sharing of resilience-related data, and cross-domain training of next-generation researchers in this field.

AB - Exposure of biological systems to acute or chronic insults triggers a host of molecular and physiological responses to either tolerate, adapt, or fully restore homeostasis; these responses constitute the hallmarks of resilience. Given the many facets, dimensions, and discipline-specific focus, gaining a shared understanding of “resilience” has been identified as a priority for supporting advances in cardiovascular health. This report is based on the working definition: “Resilience is the ability of living systems to successfully maintain or return to homeostasis in response to physical, molecular, individual, social, societal, or environmental stressors or challenges,” developed after considering many factors contributing to cardiovascular resilience through deliberations of multidisciplinary experts convened by the National Heart, Lung, and Blood Institute during a workshop entitled: “Enhancing Resilience for Cardiovascular Health and Wellness.” Some of the main emerging themes that support the possibility of enhancing resilience for cardiovascular health include optimal energy management and substrate diversity, a robust immune system that safeguards tissue homeostasis, and social and community support. The report also highlights existing research challenges, along with immediate and long-term opportunities for resilience research. Certain immediate opportunities identified are based on leveraging existing high-dimensional data from longitudinal clinical studies to identify vascular resilience measures, create a ‘resilience index,’ and adopt a life-course approach. Long-term opportunities include developing quantitative cell/organ/system/community models to identify resilience factors and mechanisms at these various levels, designing experimental and clinical interventions that specifically assess resilience, adopting global sharing of resilience-related data, and cross-domain training of next-generation researchers in this field.

KW - adaptation

KW - aging

KW - cardiovascular disease

KW - cardiovascular health

KW - genetic plasticity

KW - health disparities

KW - homeostasis

KW - resilience

KW - stress

UR - http://www.scopus.com/inward/record.url?scp=85141205219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85141205219&partnerID=8YFLogxK

U2 - 10.1096/fj.202201407R

DO - 10.1096/fj.202201407R

M3 - Article

C2 - 36322029

AN - SCOPUS:85141205219

SN - 0892-6638

VL - 36

JO - FASEB Journal

JF - FASEB Journal

IS - 12

M1 - e22639

ER -

Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this