SCN1A variants associated with sudden infant death syndrome

Catherine A. Brownstein, Richard D. Goldstein, Christopher H. Thompson, Robin L. Haynes, Emma Giles, Beth Sheidley, Matthew Bainbridge, Elisabeth A. Haas, Othon J. Mena, Jonathan Lucas, Bethann Schaber, Ingrid A. Holm, Alfred L. George, Hannah C. Kinney, Annapurna H. Poduri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We identified SCN1A variants in 2 infants who died of sudden infant death syndrome (SIDS) with hippocampal abnormalities from an exome sequencing study of 10 cases of SIDS but no history of seizures. One harbored SCN1A G682V, and the other had 2 SCN1A variants in cis: L1296M and E1308D, a variant previously associated with epilepsy. Functional evaluation in a heterologous expression system demonstrated partial loss of function for both G682V and the compound variant L1296M/E1308D. Our cases represent a novel association between SCN1A and SIDS, extending the SCN1A spectrum from epilepsy to SIDS. Our findings provide insights into SIDS and support genetic evaluation focused on epilepsy genes in SIDS.

Original languageEnglish (US)
Pages (from-to)e56-e62
JournalEpilepsia
Volume59
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • dentate gyrus
  • epilepsy
  • hippocampus
  • sodium channel
  • sudden unexpected death

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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