Scorpion venom decreases lung liquid clearance in rats

Alejandro P. Comellas, Liuska M. Pesce, Zaher Azzam, Fernando J. Saldías, Jacob I. Sznajder*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

It has been reported that scorpion venom causes respiratory failure and pulmonary edema. However, the effects of this toxin on lung edema clearance have not been previously studied. We examined the effects of scorpion (Tityus serrulatus) venom on the ability of the lung to clear fluid and on alveolar epithelial Na,K-ATPase. The wet-to-dry lung weight ratio was increased in anesthetized rats injected intraperitonally with scorpion venom. Lung edema clearance decreased by up to approximately 60% in rats injected with the venom. Na,K-ATPase α1- and β1-subunit protein abundance and activity decreased at the basolateral membranes of alveolar epithelial type II cells incubated with scorpion venom as compared with that of control animals. There was no difference in cell injury in alveolar epithelial type II cells incubated with scorpion venom for 60 minutes compared with that of control animals. We provide here the first evidence that scorpion venom decreases lung liquid clearance, probably by downregulating Na,K-ATPase in the alveolar epithelium.

Original languageEnglish (US)
Pages (from-to)1064-1067
Number of pages4
JournalAmerican journal of respiratory and critical care medicine
Volume167
Issue number8
DOIs
StatePublished - Apr 15 2003

Keywords

  • Alveolar epithelial cells
  • Na,K-ATPase
  • Scorpion venom
  • Sodium transport

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Scorpion venom decreases lung liquid clearance in rats'. Together they form a unique fingerprint.

Cite this