Screening, Diagnosis, and Treatment of Alcohol-Related Liver Disease and Alcohol-Associated Hepatitis

Parita V. Patel, Steven L. Flamm*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Alcohol-related liver disease is a spectrum of disease in which continued, significant alcohol use can cause progression from fatty changes in the liver to inflammation, fibrosis, and eventually cirrhosis. The rates of alcohol consumption, alcohol use disorder, and alcohol-related liver disease have increased substantially during the past several years. However, the amount of alcohol consumption may not be the only risk factor for such progression of disease. Studies have found several other risk factors, including sex, race, and genetic predisposition, as possible culprits of worsening disease. As a result, clinicians must understand and implement screening tools for early diagnosis and remain up-to-date with the evolving nature of treatment options. This article reviews the diagnosis and treatment of alcohol use disorder as well as the pathophysiology, clinical presentation, and treatment of alcohol-related liver disease, including alcohol-associated hepatitis.

Original languageEnglish (US)
Pages (from-to)409-417
Number of pages9
JournalGastroenterology and Hepatology
Issue number7
StatePublished - Jul 2022


  • Alcohol use disorder
  • alcohol-associated hepatitis
  • alcohol-related liver disease
  • liver transplantation

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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