Screening for and Management of Chronic Kidney Disease for Children with Congenital Abnormalities of the Kidney and Urinary Tract

Belinda Li*, David Chu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: Congenital abnormalities of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease (CKD) in children. Our objective is to review the current diagnosis and management of CAKUT, with a focus on kidney function outcomes. Recent Findings: The rate of detection of CAKUT has increased with routine prenatal ultrasonography. Despite earlier detection, children with CAKUT are still at risk for future CKD. Several tools offer prognostic information on renal function, including traditional urinary testing for proteinuria and more contemporary biomarkers. Blood pressure monitoring may identify those at risk for cardiac morbidity, whereas strict blood pressure control may delay CKD progression. Aspects of medical and surgical treatments for CAKUT are still debatable. Summary: CAKUT are a complex entity that should involve a multidisciplinary team to determine the indications for medical and surgical interventions to reduce the morbidity associated with CKD.

Original languageEnglish (US)
Pages (from-to)237-245
Number of pages9
JournalCurrent Pediatrics Reports
Volume6
Issue number3
DOIs
StatePublished - Sep 2018

Keywords

  • CAKUT
  • Chronic kidney disease in children
  • Kidney function outcomes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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