Screening for celiac disease: US preventive services task force recommendation statement

Kirsten Bibbins-Domingo; David C. Grossman; Susan J. Curry; Michael J. Barry; Karina W. Davidson; Chyke A. Doubeni; Mark Ebell; John W. Epling; Jessica Herzstein; Alex R. Kemper; Alex H. Krist; Ann E. Kurth; C. Seth Landefeld; Carol M. Mangione; Maureen G. Phipps; Michael Silverstein; Melissa A. Simon; Chien Wen Tseng; US Preventive Services Task Force

doi:10.1001/jama.2017.1462

Screening for celiac disease: US preventive services task force recommendation statement

Kirsten Bibbins-Domingo^*, David C. Grossman, Susan J. Curry, Michael J. Barry, Karina W. Davidson, Chyke A. Doubeni, Mark Ebell, John W. Epling, Jessica Herzstein, Alex R. Kemper, Alex H. Krist, Ann E. Kurth, C. Seth Landefeld, Carol M. Mangione, Maureen G. Phipps, Michael Silverstein, Melissa A. Simon, Chien Wen Tseng, US Preventive Services Task Force

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

IMPORTANCE Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye,and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. OBJECTIVE To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease. EVIDENCE REVIEW The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic adults, adolescents, and children; the potential benefits and harms of screening vs not screening and targeted vs universal screening; and the benefits and harms of treatment of screen-detected celiac disease. The USPSTF also reviewed contextual information on the prevalence of celiac disease among patients without obvious symptoms and the natural history of subclinical celiac disease. FINDINGS The USPSTF found inadequate evidence on the accuracy of screening for celiac disease, the potential benefits and harms of screening vs not screening or targeted vs universal screening, and the potential benefits and harms of treatment of screen-detected celiac disease. CONCLUSIONS AND RECOMMENDATION The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for celiac disease in asymptomatic persons.

Original language	English (US)
Pages (from-to)	1252-1257
Number of pages	6
Journal	JAMA - Journal of the American Medical Association
Volume	317
Issue number	12
DOIs	https://doi.org/10.1001/jama.2017.1462
State	Published - Mar 28 2017

Funding

The USPSTF is an independent, voluntary body. The US Congress mandates that the Agency for Healthcare Research and Quality (AHRQ) support the operations of the USPSTF. Role of the Funder/Sponsor: AHRQ staff assisted in the following: development and review of the research plan, commission of the systematic evidence review from an Evidence-based Practice Center, coordination of expert review and public comment of the draft evidence report and draft recommendation statement, and the writing and preparation of the final recommendation statement and its submission for publication. AHRQ staff had no role in the approval of the final recommendation statement or the decision to submit for publication.

ASJC Scopus subject areas

General Medicine

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10.1001/jama.2017.1462

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Bibbins-Domingo, K., Grossman, D. C., Curry, S. J., Barry, M. J., Davidson, K. W., Doubeni, C. A., Ebell, M., Epling, J. W., Herzstein, J., Kemper, A. R., Krist, A. H., Kurth, A. E., Landefeld, C. S., Mangione, C. M., Phipps, M. G., Silverstein, M., Simon, M. A., Tseng, C. W., & US Preventive Services Task Force (2017). Screening for celiac disease: US preventive services task force recommendation statement. JAMA - Journal of the American Medical Association, 317(12), 1252-1257. https://doi.org/10.1001/jama.2017.1462

@article{a58d1475e8434c9c97c41ce4d3b1908e,

title = "Screening for celiac disease: US preventive services task force recommendation statement",

abstract = "IMPORTANCE Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye,and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. OBJECTIVE To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease. EVIDENCE REVIEW The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic adults, adolescents, and children; the potential benefits and harms of screening vs not screening and targeted vs universal screening; and the benefits and harms of treatment of screen-detected celiac disease. The USPSTF also reviewed contextual information on the prevalence of celiac disease among patients without obvious symptoms and the natural history of subclinical celiac disease. FINDINGS The USPSTF found inadequate evidence on the accuracy of screening for celiac disease, the potential benefits and harms of screening vs not screening or targeted vs universal screening, and the potential benefits and harms of treatment of screen-detected celiac disease. CONCLUSIONS AND RECOMMENDATION The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for celiac disease in asymptomatic persons.",

author = "Kirsten Bibbins-Domingo and Grossman, \{David C.\} and Curry, \{Susan J.\} and Barry, \{Michael J.\} and Davidson, \{Karina W.\} and Doubeni, \{Chyke A.\} and Mark Ebell and Epling, \{John W.\} and Jessica Herzstein and Kemper, \{Alex R.\} and Krist, \{Alex H.\} and Kurth, \{Ann E.\} and Landefeld, \{C. Seth\} and Mangione, \{Carol M.\} and Phipps, \{Maureen G.\} and Michael Silverstein and Simon, \{Melissa A.\} and Tseng, \{Chien Wen\} and \{US Preventive Services Task Force\}",

note = "Funding Information: The USPSTF is an independent, voluntary body. The US Congress mandates that the Agency for Healthcare Research and Quality (AHRQ) support the operations of the USPSTF. Role of the Funder/Sponsor: AHRQ staff assisted in the following: development and review of the research plan, commission of the systematic evidence review from an Evidence-based Practice Center, coordination of expert review and public comment of the draft evidence report and draft recommendation statement, and the writing and preparation of the final recommendation statement and its submission for publication. AHRQ staff had no role in the approval of the final recommendation statement or the decision to submit for publication. Publisher Copyright: Copyright 2017 American Medical Association. All rights reserved.",

year = "2017",

month = mar,

day = "28",

doi = "10.1001/jama.2017.1462",

language = "English (US)",

volume = "317",

pages = "1252--1257",

journal = "JAMA - Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "12",

}

Bibbins-Domingo, K, Grossman, DC, Curry, SJ, Barry, MJ, Davidson, KW, Doubeni, CA, Ebell, M, Epling, JW, Herzstein, J, Kemper, AR, Krist, AH, Kurth, AE, Landefeld, CS, Mangione, CM, Phipps, MG, Silverstein, M, Simon, MA, Tseng, CW & US Preventive Services Task Force 2017, 'Screening for celiac disease: US preventive services task force recommendation statement', JAMA - Journal of the American Medical Association, vol. 317, no. 12, pp. 1252-1257. https://doi.org/10.1001/jama.2017.1462

TY - JOUR

T1 - Screening for celiac disease

T2 - US preventive services task force recommendation statement

AU - Bibbins-Domingo, Kirsten

AU - Grossman, David C.

AU - Curry, Susan J.

AU - Barry, Michael J.

AU - Davidson, Karina W.

AU - Doubeni, Chyke A.

AU - Ebell, Mark

AU - Epling, John W.

AU - Herzstein, Jessica

AU - Kemper, Alex R.

AU - Krist, Alex H.

AU - Kurth, Ann E.

AU - Landefeld, C. Seth

AU - Mangione, Carol M.

AU - Phipps, Maureen G.

AU - Silverstein, Michael

AU - Simon, Melissa A.

AU - Tseng, Chien Wen

AU - US Preventive Services Task Force

N1 - Funding Information: The USPSTF is an independent, voluntary body. The US Congress mandates that the Agency for Healthcare Research and Quality (AHRQ) support the operations of the USPSTF. Role of the Funder/Sponsor: AHRQ staff assisted in the following: development and review of the research plan, commission of the systematic evidence review from an Evidence-based Practice Center, coordination of expert review and public comment of the draft evidence report and draft recommendation statement, and the writing and preparation of the final recommendation statement and its submission for publication. AHRQ staff had no role in the approval of the final recommendation statement or the decision to submit for publication. Publisher Copyright: Copyright 2017 American Medical Association. All rights reserved.

PY - 2017/3/28

Y1 - 2017/3/28

N2 - IMPORTANCE Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye,and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. OBJECTIVE To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease. EVIDENCE REVIEW The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic adults, adolescents, and children; the potential benefits and harms of screening vs not screening and targeted vs universal screening; and the benefits and harms of treatment of screen-detected celiac disease. The USPSTF also reviewed contextual information on the prevalence of celiac disease among patients without obvious symptoms and the natural history of subclinical celiac disease. FINDINGS The USPSTF found inadequate evidence on the accuracy of screening for celiac disease, the potential benefits and harms of screening vs not screening or targeted vs universal screening, and the potential benefits and harms of treatment of screen-detected celiac disease. CONCLUSIONS AND RECOMMENDATION The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for celiac disease in asymptomatic persons.

AB - IMPORTANCE Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye,and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. OBJECTIVE To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease. EVIDENCE REVIEW The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic adults, adolescents, and children; the potential benefits and harms of screening vs not screening and targeted vs universal screening; and the benefits and harms of treatment of screen-detected celiac disease. The USPSTF also reviewed contextual information on the prevalence of celiac disease among patients without obvious symptoms and the natural history of subclinical celiac disease. FINDINGS The USPSTF found inadequate evidence on the accuracy of screening for celiac disease, the potential benefits and harms of screening vs not screening or targeted vs universal screening, and the potential benefits and harms of treatment of screen-detected celiac disease. CONCLUSIONS AND RECOMMENDATION The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for celiac disease in asymptomatic persons.

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U2 - 10.1001/jama.2017.1462

DO - 10.1001/jama.2017.1462

M3 - Review article

C2 - 28350936

AN - SCOPUS:85016629994

SN - 0098-7484

VL - 317

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JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

IS - 12

ER -

Screening for celiac disease: US preventive services task force recommendation statement

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