Screening of living organ donors for endemic infections: Understanding the challenges and benefits of enhanced screening

Amanda Rosen, Michael G Ison*

*Corresponding author for this work

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Living organ donor candidates are screened for medical and psychosocial contraindications to donation. One important goal of this process is to prevent donor-derived infectious diseases transmissions. These transmissions are exceptionally rare, but have the potential to cause significant morbidity and mortality. The Organ Procurement and Transplantation Network now requires each recovery hospital to develop a protocol for evaluating living donors for tuberculosis and other geographically defined endemic pathogens, including Trypanosoma cruzi (the causative pathogen of Chagas’ disease), Strongyloides stercoralis, and West Nile Virus (WNV), in addition to universal screening for blood-borne pathogens. Enhanced screening requirements were developed in response to the changing epidemiology and endemicity of these diseases, as well as recent case reports of donor-derived disease transmission. Living organ donor disease screening presents a number of unique challenges to clinicians and policy-makers, including deciding which donors to test, which testing modality to use, when to test, and appropriate interpretation of results. This review will analyze the epidemiology of T. cruzi, S. stercoralis, and WNV, the assays available for screening for these diseases, and the subsequent impact on the living organ donor process.

Original languageEnglish (US)
Article numbere12633
JournalTransplant Infectious Disease
Volume19
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • donor screening
  • infectious diseases
  • living donation

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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