Screening recipients of increased risk donor organs: A multicenter retrospective study

Michael G Ison, Meenakshi M. Rana, Kyle D. Brizendine, Sonia Chimienti, Jade Le, Rosette Kfoury, Parvin Mohazabnia, Nicole Theodoropoulos*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8%) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25%-43%) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.

Original languageEnglish (US)
Article numbere12862
JournalTransplant Infectious Disease
Volume20
Issue number3
DOIs
StatePublished - Jun 1 2018

Fingerprint

Multicenter Studies
Retrospective Studies
Tissue Donors
HIV
Transplants
Tissue and Organ Procurement
Research Ethics Committees
Serology
Hepatitis B virus
Hepacivirus
Transplantation
Infection
Transplant Recipients

Keywords

  • HIV
  • PHS increased risk donors
  • hepatitis B
  • hepatitis C
  • organ recipients
  • screening

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Ison, M. G., Rana, M. M., Brizendine, K. D., Chimienti, S., Le, J., Kfoury, R., ... Theodoropoulos, N. (2018). Screening recipients of increased risk donor organs: A multicenter retrospective study. Transplant Infectious Disease, 20(3), [e12862]. https://doi.org/10.1111/tid.12862
Ison, Michael G ; Rana, Meenakshi M. ; Brizendine, Kyle D. ; Chimienti, Sonia ; Le, Jade ; Kfoury, Rosette ; Mohazabnia, Parvin ; Theodoropoulos, Nicole. / Screening recipients of increased risk donor organs : A multicenter retrospective study. In: Transplant Infectious Disease. 2018 ; Vol. 20, No. 3.
@article{b908f7b19330483ea01582cc7fd2671b,
title = "Screening recipients of increased risk donor organs: A multicenter retrospective study",
abstract = "Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60{\%}) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8{\%}) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25{\%}-43{\%}) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.",
keywords = "HIV, PHS increased risk donors, hepatitis B, hepatitis C, organ recipients, screening",
author = "Ison, {Michael G} and Rana, {Meenakshi M.} and Brizendine, {Kyle D.} and Sonia Chimienti and Jade Le and Rosette Kfoury and Parvin Mohazabnia and Nicole Theodoropoulos",
year = "2018",
month = "6",
day = "1",
doi = "10.1111/tid.12862",
language = "English (US)",
volume = "20",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "3",

}

Ison, MG, Rana, MM, Brizendine, KD, Chimienti, S, Le, J, Kfoury, R, Mohazabnia, P & Theodoropoulos, N 2018, 'Screening recipients of increased risk donor organs: A multicenter retrospective study', Transplant Infectious Disease, vol. 20, no. 3, e12862. https://doi.org/10.1111/tid.12862

Screening recipients of increased risk donor organs : A multicenter retrospective study. / Ison, Michael G; Rana, Meenakshi M.; Brizendine, Kyle D.; Chimienti, Sonia; Le, Jade; Kfoury, Rosette; Mohazabnia, Parvin; Theodoropoulos, Nicole.

In: Transplant Infectious Disease, Vol. 20, No. 3, e12862, 01.06.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Screening recipients of increased risk donor organs

T2 - A multicenter retrospective study

AU - Ison, Michael G

AU - Rana, Meenakshi M.

AU - Brizendine, Kyle D.

AU - Chimienti, Sonia

AU - Le, Jade

AU - Kfoury, Rosette

AU - Mohazabnia, Parvin

AU - Theodoropoulos, Nicole

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8%) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25%-43%) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.

AB - Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8%) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25%-43%) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.

KW - HIV

KW - PHS increased risk donors

KW - hepatitis B

KW - hepatitis C

KW - organ recipients

KW - screening

UR - http://www.scopus.com/inward/record.url?scp=85044416258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044416258&partnerID=8YFLogxK

U2 - 10.1111/tid.12862

DO - 10.1111/tid.12862

M3 - Article

C2 - 29512233

AN - SCOPUS:85044416258

VL - 20

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

SN - 1398-2273

IS - 3

M1 - e12862

ER -