Screening recipients of increased risk donor organs: A multicenter retrospective study

Michael G. Ison; Meenakshi M. Rana; Kyle D. Brizendine; Sonia Chimienti; Jade Le; Rosette Kfoury; Parvin Mohazabnia; Nicole Theodoropoulos

doi:10.1111/tid.12862

Screening recipients of increased risk donor organs: A multicenter retrospective study

Michael G. Ison, Meenakshi M. Rana, Kyle D. Brizendine, Sonia Chimienti, Jade Le, Rosette Kfoury, Parvin Mohazabnia, Nicole Theodoropoulos^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8%) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25%-43%) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.

Original language	English (US)
Article number	e12862
Journal	Transplant Infectious Disease
Volume	20
Issue number	3
DOIs	https://doi.org/10.1111/tid.12862
State	Published - Jun 2018

Keywords

HIV
PHS increased risk donors
hepatitis B
hepatitis C
organ recipients
screening

ASJC Scopus subject areas

Infectious Diseases
Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.12862

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title = "Screening recipients of increased risk donor organs: A multicenter retrospective study",

abstract = "Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8%) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25%-43%) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.",

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note = "Funding Information: The use of REDCap was made possible by The Ohio State University Center for Clinical and Translational Science grant support (National Center for Advancing Translational Sciences, Grant UL1TR001070). Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2018",

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doi = "10.1111/tid.12862",

language = "English (US)",

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AU - Ison, Michael G.

AU - Rana, Meenakshi M.

AU - Brizendine, Kyle D.

AU - Chimienti, Sonia

AU - Le, Jade

AU - Kfoury, Rosette

AU - Mohazabnia, Parvin

AU - Theodoropoulos, Nicole

N1 - Funding Information: The use of REDCap was made possible by The Ohio State University Center for Clinical and Translational Science grant support (National Center for Advancing Translational Sciences, Grant UL1TR001070). Publisher Copyright: © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

PY - 2018/6

Y1 - 2018/6

N2 - Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8%) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25%-43%) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.

AB - Organ Procurement & Transplantation Network policy requires post-transplant screening of recipients of organs from donors at increased risk for transmission of HIV, hepatitis B virus, and hepatitis C virus. Available data suggest that follow-up testing of recipients is not routinely conducted. Data on increased risk donors and recipients of their organs from 2008 to 2012 were retrospectively collected from 6 transplant centers after IRB approval. Descriptive statistics were performed. About 363 (60%) recipients were screened for transmission of HIV, HBV, and/or HCV at some time point; 257 (70.8%) within 90 days of transplant. The type of test used to screen for infection was variable with many recipients (25%-43%) screened with serology alone. Our results reveal that post-transplant screening for HIV, HBV, and HCV in recipients of increased risk donor organs did not universally occur and testing methods were variable.

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KW - hepatitis B

KW - hepatitis C

KW - organ recipients

KW - screening

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Screening recipients of increased risk donor organs: A multicenter retrospective study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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