Script generation as an indicator of knowledge representation in patients with Alzheimer's disease

Jordan Grafman*, Karen Thompson, Herbert Weingartner, Rick Martinez, Brian A. Lawlor, Trey Sunderland

*Corresponding author for this work

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We examined script and lexical retrieval in patients with probable Dementia-Alzheimer's Type (DAT), Depressed patients, and normal controls. DAT patient breakdown in script production was structurally similar to their impaired lexical retrieval such that script events of low frequency and low centrality value were lost first. DAT patients also produced more events that fell outside the script boundary as well as more event-order errors. Four cases with DAT were identified on the basis of Z scores whose script production was at least 2 SDs greater than their lexical production or vice versa. This finding suggests that it may be possible to dissociate script and lexical knowledge and production processes. The findings lend partial support for a model of knowledge representation that includes parallel and partially redundant memory networks that are distinctly distributed in the brain.

Original languageEnglish (US)
Pages (from-to)344-358
Number of pages15
JournalBrain and Language
Volume40
Issue number3
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

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