Seasonal variation of ige antibody specific for ragweed antigen e (ige-a-age) from the basophil surface in patients with ragweed pollenosis

Leslie Grammer, Doris Levitz, Mary Roberts, Jacob J. Pruzansky, C. Raymond Zeiss*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Seasonal elevation in total serum IgE and IgE antibody specific for antigen E (IgE-a-AgE) are well recognized in patients with ragweed pollenosis. We found that the ratio of specific IgE-a-AgE to total IgE in plasma was the only measure predictive of the number of specific IgE-a-AgE molecules per basophil. Although both total and specific IgE rose with season, the ratio did not change, the number of IgE-a-AgE molecules per basophil did not change, and histamine release in response to AgE did not increase.

Original languageEnglish (US)
Pages (from-to)179-188
Number of pages10
JournalInternational archives of allergy and immunology
Volume66
Issue number2
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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